NP_201582.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,168 Da
NCBI Official Full Name
lysyl oxidase homolog 2
NCBI Official Synonym Full Names
lysyl oxidase-like 2
NCBI Official Synonym Symbols
1110004B06Rik; 4930526G11Rik; 9430067E15Rik [Similar Products]
NCBI Protein Information
lysyl oxidase homolog 2
UniProt Protein Name
Lysyl oxidase homolog 2
UniProt Synonym Protein Names
Lysyl oxidase-like protein 2
UniProt Comments for LOXL2
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
Research Articles on LOXL2
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Products associated with LOXL2 elisa kit
Diseases associated with LOXL2 elisa kit
Organs/Tissues associated with LOXL2 elisa kit
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