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CCL22 elisa kit :: Mouse MDC ELISA Kit

Scan QR to view Datasheet Catalog #    MBS175846
 Typical Testing Data/Standard Curve
Unit / Price
96-Strip-Wells  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MDC (CCL22), ELISA Kit

 Also Known As   

Mouse MDC PicoKine ELISA Kit

 Product Synonym Names    C-C motif chemokine 22; chemokine (C-C motif) ligand 22; A-152E5.1; ABCD 1; ABCD1; C-C motif chemokine 22; CC chemokine STCP-1; Ccl22; CCL22_HUMAN; Chemokine (C-C motif) ligand 22; DC/B-CK; Macrophage-derived chemokine; MDC(1-69); MDC(7-69); MGC34554; SCYA22; Small inducible cytokine A22; Small inducible cytokine subfamily A (Cys-Cys), member 22; Small-inducible cytokine A22; STCP 1; STCP1; Stimulated T cell chemotactic protein 1; Stimulated T-cell chemotactic protein 1
 Product Gene Name   

CCL22 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O88430
 Species Reactivity    Mouse
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 Specificity    Natural and recombinant mouse MDC
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 Samples    Cell culture supernates, serum and plasma (heparin, EDTA)
 Assay Type    Sandwich
 Detection Range    15.6pg/ml-1000pg/ml
 Sensitivity    < 1pg/ml
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CCL22 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CCL22 purchase    MBS175846 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the MDC (CCL22) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6pg/ml-1000pg/ml in biological research samples containing CCL22, with an estimated sensitivity of < 1pg/ml. The ELISA analytical biochemical technique of the MBS175846 kit is based on CCL22 antibody-CCL22 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CCL22 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CCL22. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for CCL22 elisa kit

   Principle of the assay: mouse MDC ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from rat specific for MDC has been precoated onto 96-well plates. Standards (E.coli, G25-S92) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for MDC is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the mouse MDC amount of sample captured in plate.
Background: Macrophage-derived chemokine (MDC), also called Chemokine, cc motif, ligand 22 (CCL22) or Small inducible cytokine subfamily A, member 22 (SCY22). MDC is a recently identified member of the CC chemokine family. It is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. In addition, MDC gene is mapped to chromosome 16q13, the same position reported for the TARC gene. MDC has the four-cysteine motif and other highly conserved residues characteristic of CC chemokines, but it shares <35% identity with any of the known chemokines. Recombinant MDC was expressed in Chinese hamster ovary cells and purified by heparin-Sepharose chromatography. MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin. High expression was also detected in normal thymus and less expression in lung and spleen. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes.
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  Typical Testing Data/Standard Curve of CCL22 elisa kit    Mouse MDC PicoKine ELISA Kit standard curve
CCL22 elisa kit  Typical Testing Data/Standard Curve image
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Sample Manual Insert of MBS175846. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CCL22. It may not necessarily be applicable to this product.
 NCBI GI #    6094388
 NCBI GeneID    20299
 NCBI Accession #    O88430.1 [Other Products]
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 UniProt Primary Accession #    O88430 [Other Products]
 UniProt Related Accession #    O88430 [Other Products]
 Molecular Weight    10,302 Da
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 NCBI Official Full Name    C-C motif chemokine 22
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 22
 NCBI Official Symbol    Ccl22 [Similar Products]
 NCBI Official Synonym Symbols   
MDC; DCBCK; ABCD-1; Scya22
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 22; CC chemokine ABCD-1; small-inducible cytokine A22; activated B and dendritic cell-derived; small inducible cytokine subfamily A22; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED)
 UniProt Protein Name    C-C motif chemokine 22
 UniProt Synonym Protein Names   
Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22
 Protein Family    C-C motif chemokine
 UniProt Gene Name    Ccl22 [Similar Products]
 UniProt Synonym Gene Names    Abcd1; Scya22 [Similar Products]
 UniProt Entry Name    CCL22_MOUSE
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 UniProt Comments for CCL22    CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Chemokine

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; cytokine activity

Biological Process: immune response; chemotaxis; inflammatory response
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 Research Articles on CCL22    1. islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL22 elisa kitPathways associated with CCL22 elisa kit
 Reference Product  PubMed Publications
 Ccr4 elisa kit  >219 publications with CCL22 and Ccr4
 Ccl11 elisa kit  >57 publications with CCL22 and Ccl11
 Cxcr3 elisa kit  >43 publications with CCL22 and Cxcr3
 Ccr5 elisa kit  >40 publications with CCL22 and Ccr5
 Ccr7 elisa kit  >38 publications with CCL22 and Ccr7
 Ccr3 elisa kit  >27 publications with CCL22 and Ccr3
 Ccr8 elisa kit  >25 publications with CCL22 and Ccr8
 Ccl7 elisa kit  >22 publications with CCL22 and Ccl7
 Ccr2 elisa kit  >15 publications with CCL22 and Ccr2
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with CCL22 elisa kitOrgans/Tissues associated with CCL22 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >183 publications with CCL22 and Inflammation
 Hypersensitivity Antibodies  >140 publications with CCL22 and Hypersensitivity
 Skin Diseases Antibodies  >121 publications with CCL22 and Skin Diseases
 Respiratory Tract Diseases Antibodies  >116 publications with CCL22 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >100 publications with CCL22 and Lung Diseases
 Necrosis Antibodies  >74 publications with CCL22 and Necrosis
 Dermatitis, Atopic Antibodies  >68 publications with CCL22 and Dermatitis, Atopic
 Respiratory Hypersensitivity Antibodies  >61 publications with CCL22 and Respiratory Hypersensitivity
 Carcinoma Antibodies  >41 publications with CCL22 and Carcinoma
 Liver Diseases Antibodies  >16 publications with CCL22 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >133 publications with CCL22 and Thymus
 Skin Antibodies  >119 publications with CCL22 and Skin
 Lymph Node Antibodies  >66 publications with CCL22 and Lymph Node
 Spleen Antibodies  >30 publications with CCL22 and Spleen
 Thyroid Antibodies  >3 publications with CCL22 and Thyroid
 Salivary Gland Antibodies  >3 publications with CCL22 and Salivary Gland
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