AAA39541.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,954 Da
NCBI Official Full Name
MHC class II H2-IA-beta-psi
NCBI Official Synonym Full Names
histocompatibility 2, class II antigen A, beta 1
NCBI Official Synonym Symbols
IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta; AI845868 [Similar Products]
NCBI Protein Information
histocompatibility 2, class II antigen A, beta 1; H-2 class II histocompatibility antigen, A beta chain; MHC class II H2-IA-beta-psi; MHC class II antigen A beta; major histocompatibility complex class II beta chain; response to metastatic cancers 1
UniProt Protein Name
H-2 class II histocompatibility antigen, A-D beta chain
UniProt Entry Name
HB2D_MOUSE
UniProt Comments for MHC-II/H-2II
HLA-DQB1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family.
Protein type: Membrane protein, integral
Cellular Component: multivesicular body; Golgi apparatus; cell surface; membrane; early endosome; plasma membrane; integral to membrane; intracellular; external side of plasma membrane; MHC class II protein complex
Molecular Function: toxin binding; protein binding; peptide antigen binding; protein heterodimerization activity; ubiquitin protein ligase binding; transcription factor binding
Biological Process: positive regulation of T-helper 1 type immune response; immune system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; immunoglobulin production during immune response; humoral immune response mediated by circulating immunoglobulin; antigen processing and presentation; antigen processing and presentation of peptide antigen; positive regulation of alpha-beta T cell activation; negative regulation of T cell proliferation; immune response; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; B cell affinity maturation; positive regulation of antigen processing and presentation
Research Articles on MHC-II/H-2II
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Pathways associated with MHC-II/H-2II elisa kit
Organs/Tissues associated with MHC-II/H-2II elisa kit
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