NP_061206.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,223 Da
NCBI Official Full Name
double-strand break repair protein MRE11A
NCBI Official Synonym Full Names
meiotic recombination 11 homolog A (S. cerevisiae)
NCBI Protein Information
double-strand break repair protein MRE11A; mmMRE11A; MRE11 homolog 1; MRE11 homolog A; meiotic recombination 11 homolog 1
UniProt Protein Name
Double-strand break repair protein MRE11A
UniProt Synonym Protein Names
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
UniProt Synonym Gene Names
UniProt Entry Name
MRE11_MOUSE
UniProt Comments for MRE11A
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: DNA repair, damage; Cell cycle regulation; DNA-binding; Deoxyribonuclease
Cellular Component: nucleoplasm; chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; perinuclear region of cytoplasm; nuclear chromatin; chromatin; nucleus
Molecular Function: protein C-terminus binding; ATP-dependent DNA helicase activity; nuclease activity; DNA binding; hydrolase activity; manganese ion binding; endonuclease activity; exonuclease activity; 3'-5' exonuclease activity
Biological Process: negative regulation of virion penetration into host cell; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; DNA repair; positive regulation of protein amino acid autophosphorylation; chromosome organization and biogenesis; DNA duplex unwinding; cell proliferation; meiotic cell cycle; base-excision repair; nucleotide-excision repair; intra-S DNA damage checkpoint; double-strand break repair; mitotic cell cycle G2/M transition DNA damage checkpoint; synapsis; response to DNA damage stimulus; telomere maintenance; DNA metabolic process
Research Articles on MRE11A
Precautions
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Pathways associated with MRE11A elisa kit
Diseases associated with MRE11A elisa kit
Organs/Tissues associated with MRE11A elisa kit
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