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M-CSFR elisa kit :: Mouse Macrophage colony-stimulating factor receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS728377 M-CSFR elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage colony-stimulating factor receptor (M-CSFR), ELISA Kit

 Also Known As   

Mouse Macrophage colony-stimulating factor receptor ELISA Kit

 Product Gene Name   

M-CSFR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    gene 221820
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 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of M-CSFR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for M-CSFR purchase    MBS728377 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Macrophage colony-stimulating factor receptor (M-CSFR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing M-CSFR. The ELISA analytical biochemical technique of the MBS728377 kit is based on M-CSFR antibody-M-CSFR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect M-CSFR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, M-CSFR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for M-CSFR elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for M-CSFR. It may not necessarily be applicable to this product.
 NCBI GI #    27262659
 NCBI GeneID    1436
 NCBI Accession #    NP_005202.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005211.3 [Other Products]
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 UniProt Secondary Accession #    Q6LDW5; Q6LDY4; Q86VW7; B5A955; D3DQG2 [Other Products]
 UniProt Related Accession #    P07333 [Other Products]
 Molecular Weight    33,248 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
 UniProt Entry Name    CSF1R_HUMAN
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 NCBI Summary for M-CSFR    The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for M-CSFR    CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Protein kinase, TK; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding

Biological Process: regulation of bone resorption; macrophage differentiation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; monocyte differentiation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; cell proliferation; regulation of cell shape; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; positive regulation of protein amino acid phosphorylation; phosphatidylinositol metabolic process; intercellular junction maintenance; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
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 Research Articles on M-CSFR    1. haploinsufficiency of CSF-1R is sufficient to cause Hereditary diffuse leukoencephalopathy with spheroids [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with M-CSFR elisa kitPathways associated with M-CSFR elisa kit
 Reference Product  PubMed Publications
 CSF1 elisa kit  >88 publications with M-CSFR and CSF1
 GRB2 elisa kit  >52 publications with M-CSFR and GRB2
 CBL elisa kit  >39 publications with M-CSFR and CBL
 MYB elisa kit  >20 publications with M-CSFR and MYB
 TYROBP elisa kit  >14 publications with M-CSFR and TYROBP
 IL34 elisa kit  >4 publications with M-CSFR and IL34
 ITGB3 elisa kit  >3 publications with M-CSFR and ITGB3
 RASA1 elisa kit  >1 publications with M-CSFR and RASA1
 PIK3R1 elisa kit  >1 publications with M-CSFR and PIK3R1
 SPI1 elisa kit  >1 publications with M-CSFR and SPI1
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with M-CSFR elisa kitOrgans/Tissues associated with M-CSFR elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1274 publications with M-CSFR and Necrosis
 Inflammation Antibodies  >704 publications with M-CSFR and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >376 publications with M-CSFR and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >295 publications with M-CSFR and Lung Diseases
 Cardiovascular Diseases Antibodies  >167 publications with M-CSFR and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >161 publications with M-CSFR and Neoplasms, Experimental
 Lymphoma Antibodies  >158 publications with M-CSFR and Lymphoma
 Breast Neoplasms Antibodies  >151 publications with M-CSFR and Breast Neoplasms
 Lung Neoplasms Antibodies  >75 publications with M-CSFR and Lung Neoplasms
 Kidney Diseases Antibodies  >70 publications with M-CSFR and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3147 publications with M-CSFR and Blood
 Bone Antibodies  >1953 publications with M-CSFR and Bone
 Bone Marrow Antibodies  >1428 publications with M-CSFR and Bone Marrow
 Lung Antibodies  >411 publications with M-CSFR and Lung
 Spleen Antibodies  >269 publications with M-CSFR and Spleen
 Brain Antibodies  >245 publications with M-CSFR and Brain
 Liver Antibodies  >201 publications with M-CSFR and Liver
 Muscle Antibodies  >135 publications with M-CSFR and Muscle
 Kidney Antibodies  >135 publications with M-CSFR and Kidney
 Embryonic Tissue Antibodies  >127 publications with M-CSFR and Embryonic Tissue
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