NP_005949.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,375 Da
NCBI Official Full Name
melatonin receptor type 1A
NCBI Official Synonym Full Names
melatonin receptor 1A
NCBI Protein Information
melatonin receptor type 1A; mel1a receptor
UniProt Protein Name
Melatonin receptor type 1A
UniProt Synonym Gene Names
UniProt Entry Name
MTR1A_HUMAN
NCBI Summary for MT
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
UniProt Comments for MT
MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein binding; hormone binding; melatonin receptor activity
Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior
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Products associated with MT elisa kit
Pathways associated with MT elisa kit
Diseases associated with MT elisa kit
Organs/Tissues associated with MT elisa kit
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