NP_006163.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,708 Da
NCBI Official Full Name
natriuretic peptides A preproprotein
NCBI Official Synonym Full Names
natriuretic peptide A
NCBI Official Synonym Symbols
ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF [Similar Products]
NCBI Protein Information
natriuretic peptides A; atriopeptin; cardionatrin; natriuretic peptide precursor A; prepronatriodilatin
UniProt Protein Name
Natriuretic peptides A
UniProt Synonym Protein Names
CDD-ANF; Cardiodilatin; CDD; Cardiodilatin-related peptide; CDP; PrepronatriodilatinAtrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP
UniProt Synonym Gene Names
UniProt Entry Name
ANF_HUMAN
NCBI Summary for NT-proBNP
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
UniProt Comments for NT-proBNP
NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.
Protein type: Secreted; Secreted, signal peptide; Hormone
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus
Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; receptor binding
Biological Process: cardiac muscle hypertrophy; cGMP biosynthetic process; transcription initiation from RNA polymerase II promoter; negative regulation of systemic arterial blood pressure; positive regulation of heart rate; female pregnancy; response to insulin stimulus; neuropeptide signaling pathway; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; response to hypoxia; gene expression; negative regulation of cell growth; regulation of blood vessel size
Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6
Research Articles on NT-proBNP
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Products associated with NT-proBNP elisa kit
Pathways associated with NT-proBNP elisa kit
Diseases associated with NT-proBNP elisa kit
Organs/Tissues associated with NT-proBNP elisa kit
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