AAH17568.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,722 Da
NCBI Official Full Name
Neuregulin 4
NCBI Official Synonym Full Names
neuregulin 4
NCBI Official Synonym Symbols
NCBI Protein Information
pro-neuregulin-4, membrane-bound isoform
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
UniProt Synonym Gene Names
UniProt Entry Name
NRG4_HUMAN
NCBI Summary for NRG-4
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
UniProt Comments for NRG-4
NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane
Molecular Function: growth factor activity; protein binding; receptor binding
Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; organ development; phosphoinositide-mediated signaling; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Research Articles on NRG-4
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Products associated with NRG-4 elisa kit
Pathways associated with NRG-4 elisa kit
Diseases associated with NRG-4 elisa kit
Organs/Tissues associated with NRG-4 elisa kit
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