NP_001032898.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,612 Da
NCBI Official Full Name
cadherin-3 isoform a preproprotein
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Synonym Symbols
Cadp; Cdhp; Pcad; AI385538; P-cadherin [Similar Products]
NCBI Protein Information
cadherin-3; placental cadherin; RPE-specific cadherin
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CADH3_MOUSE
NCBI Summary for CDH3
This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for CDH3
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: cell-cell adherens junction; membrane; cytoplasm; integral to membrane; plasma membrane
Molecular Function: metal ion binding; calcium ion binding
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; negative regulation of transforming growth factor-beta2 production; retinal homeostasis; hair cycle process; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; keratinization; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; cell adhesion; homophilic cell adhesion
Research Articles on CDH3
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Products associated with CDH3 elisa kit
Pathways associated with CDH3 elisa kit
Diseases associated with CDH3 elisa kit
Organs/Tissues associated with CDH3 elisa kit
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