NP_001018119.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,113 Da
NCBI Official Full Name
pirin
NCBI Official Synonym Full Names
pirin (iron-binding nuclear protein)
NCBI Protein Information
pirin; probable quercetin 2,3-dioxygenase PIR; probable quercetinase
UniProt Protein Name
Pirin
UniProt Synonym Protein Names
Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase
UniProt Synonym Gene Names
UniProt Entry Name
PIR_HUMAN
NCBI Summary for PIR
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for PIR
PIR: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. Highly expressed in a subset of melanomas. Detected at very low levels in most tissues. Expressed in all tissues, with highest level of expression in heart and liver. Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. Belongs to the pirin family.
Protein type: EC 1.13.11.24
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; transcription cofactor activity; quercetin 2,3-dioxygenase activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; monocyte differentiation
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Products associated with PIR elisa kit
Diseases associated with PIR elisa kit
Organs/Tissues associated with PIR elisa kit
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