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PCSK9 elisa kit :: Mouse Proprotein Convertase Subtilisin/Kexin Type 9 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008055 PCSK9 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), ELISA Kit

 Also Known As   

Mouse Proprotein Convertase Subtilisin/Kexin Type 9 ELISA Kit

 Product Gene Name   

PCSK9 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (55505149..55530526). Location: 1p32.3
 OMIM    603776
 3D Structure    ModBase 3D Structure for Q8NBP7
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 Species Reactivity    Mouse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PCSK9 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PCSK9 purchase    MBS008055 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PCSK9. The ELISA analytical biochemical technique of the MBS008055 kit is based on PCSK9 antibody-PCSK9 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PCSK9 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PCSK9. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PCSK9. It may not necessarily be applicable to this product.
 NCBI GI #    31317307
 NCBI GeneID    255738
 NCBI Accession #    NP_777596.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_174936.3 [Other Products]
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 UniProt Primary Accession #    Q8NBP7 [Other Products]
 UniProt Secondary Accession #    Q5PSM5; Q5SZQ2; A8T640; C0JYY9 [Other Products]
 UniProt Related Accession #    Q8NBP7 [Other Products]
 Molecular Weight    74,286 Da
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 NCBI Official Full Name    proprotein convertase subtilisin/kexin type 9 preproprotein
 NCBI Official Synonym Full Names    proprotein convertase subtilisin/kexin type 9
 NCBI Official Symbol    PCSK9 [Similar Products]
 NCBI Official Synonym Symbols   
FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3
[Similar Products]
 NCBI Protein Information    proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein
 UniProt Protein Name    Proprotein convertase subtilisin/kexin type 9
 UniProt Synonym Protein Names   
Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9
 Protein Family    Proprotein convertase subtilisin/kexin
 UniProt Gene Name    PCSK9 [Similar Products]
 UniProt Synonym Gene Names    NARC1; NARC-1; PC9 [Similar Products]
 UniProt Entry Name    PCSK9_HUMAN
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 NCBI Summary for PCSK9    This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008]
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 UniProt Comments for PCSK9    PCSK9: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Defects in PCSK9 are the cause of hypercholesterolemia autosomal dominant type 3 (HCHOLA3). A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: Golgi apparatus; extracellular space; cell surface; extrinsic to external side of plasma membrane; rough endoplasmic reticulum; endoplasmic reticulum; lysosome; perinuclear region of cytoplasm; cytoplasm; late endosome; early endosome; plasma membrane; ER to Golgi transport vesicle

Molecular Function: very-low-density lipoprotein binding; sodium channel inhibitor activity; protein binding; protein self-association; low-density lipoprotein receptor binding; serine-type endopeptidase activity; low-density lipoprotein binding; apolipoprotein binding; apolipoprotein receptor binding

Biological Process: cholesterol metabolic process; lysosomal transport; apoptosis; positive regulation of receptor internalization; lipoprotein metabolic process; regulation of low-density lipoprotein receptor catabolic process; proteolysis; liver development; cellular response to starvation; neuron differentiation; protein autoprocessing; cholesterol homeostasis; triacylglycerol metabolic process; cellular response to insulin stimulus; neurogenesis; positive regulation of neuron apoptosis; phospholipid metabolic process; regulation of neuron apoptosis; low-density lipoprotein receptor catabolic process; negative regulation of receptor recycling; regulation of receptor activity; kidney development

Disease: Hypercholesterolemia, Autosomal Dominant, 3
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 Research Articles on PCSK9    1. The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PCSK9 elisa kitDiseases associated with PCSK9 elisa kit
 Reference Product  PubMed Publications
 LDLR elisa kit  >248 publications with PCSK9 and LDLR
 APOB elisa kit  >146 publications with PCSK9 and APOB
 SREBF2 elisa kit  >9 publications with PCSK9 and SREBF2
 VLDLR elisa kit  >7 publications with PCSK9 and VLDLR
 Disease Name  Pubmed Publications
 Hypercholesterolemia Antibodies  >276 publications with PCSK9 and Hypercholesterolemia
 Dyslipidemias Antibodies  >234 publications with PCSK9 and Dyslipidemias
 Hyperlipidemias Antibodies  >201 publications with PCSK9 and Hyperlipidemias
 Coronary Artery Disease Antibodies  >111 publications with PCSK9 and Coronary Artery Disease
 Heart Diseases Antibodies  >63 publications with PCSK9 and Heart Diseases
 Hypercholesterolemia, Autosomal Dominant, 3 Antibodies  >42 publications with PCSK9 and Hypercholesterolemia, Autosomal Dominant, 3
 Liver Diseases Antibodies  >17 publications with PCSK9 and Liver Diseases
 Myocardial Infarction Antibodies  >16 publications with PCSK9 and Myocardial Infarction
 Fatty Liver Antibodies  >13 publications with PCSK9 and Fatty Liver
 Insulin Resistance Antibodies  >12 publications with PCSK9 and Insulin Resistance
Organs/Tissues associated with PCSK9 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >126 publications with PCSK9 and Liver
 Brain Antibodies  >12 publications with PCSK9 and Brain
 Intestine Antibodies  >9 publications with PCSK9 and Intestine
 Embryonic Tissue Antibodies  >4 publications with PCSK9 and Embryonic Tissue
 Connective Tissue Antibodies  >3 publications with PCSK9 and Connective Tissue
 Pancreas Antibodies  >2 publications with PCSK9 and Pancreas
 Ovary Antibodies  >2 publications with PCSK9 and Ovary
 Bone Antibodies  >1 publications with PCSK9 and Bone
 Stomach Antibodies  >1 publications with PCSK9 and Stomach
 Uterus Antibodies  >1 publications with PCSK9 and Uterus
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