NP_033553.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,974 Da
NCBI Official Full Name
protein Wnt-7a
NCBI Official Synonym Full Names
wingless-type MMTV integration site family, member 7A
NCBI Protein Information
protein Wnt-7a
UniProt Protein Name
Protein Wnt-7a
UniProt Synonym Gene Names
UniProt Entry Name
WNT7A_MOUSE
UniProt Comments for Wnt7a
WNT7A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS). A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS); also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Belongs to the Wnt family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: cell surface; extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: cytokine activity; frizzled binding; protein binding; receptor agonist activity; receptor binding
Biological Process: angiogenesis; asymmetric protein localization; cartilage condensation; cartilage development; cell fate commitment; cell proliferation in forebrain; cell-cell signaling; central nervous system vasculogenesis; cerebellar granule cell differentiation; chondrocyte differentiation; dorsal/ventral pattern formation; embryonic axis specification; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; establishment of cell polarity; fallopian tube development; forelimb morphogenesis; hindlimb morphogenesis; limb development; multicellular organismal development; negative regulation of apoptosis; negative regulation of neurogenesis; neurotransmitter secretion; organ morphogenesis; palate development; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of JNK cascade; positive regulation of synaptogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of axon diameter; regulation of axonogenesis; regulation of cell proliferation; reproductive structure development; response to estrogen stimulus; satellite cell activation; satellite cell compartment self-renewal involved in skeletal muscle regeneration; signal transduction; skeletal morphogenesis; skin morphogenesis; somatic stem cell division; somatic stem cell maintenance; stem cell development; synapse organization and biogenesis; uterus development; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Research Articles on Wnt7a
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Products associated with Wnt7a elisa kit
Pathways associated with Wnt7a elisa kit
Diseases associated with Wnt7a elisa kit
Organs/Tissues associated with Wnt7a elisa kit
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