NP_680088.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
41,728 Da
NCBI Official Full Name
pulmonary surfactant-associated protein B isoform 1
NCBI Official Synonym Full Names
surfactant associated protein B
NCBI Official Synonym Symbols
SF-B; SP-B; Sftp3; Sftp-3; AI562151 [Similar Products]
NCBI Protein Information
pulmonary surfactant-associated protein B
UniProt Protein Name
Pulmonary surfactant-associated protein B
UniProt Synonym Protein Names
Pulmonary surfactant-associated proteolipid SPL(Phe)
UniProt Synonym Gene Names
UniProt Entry Name
PSPB_MOUSE
UniProt Comments for Sftpb
SFTPB: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1); also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS). RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: cytoplasm; extracellular region; extracellular space; lysosome; multivesicular body
Molecular Function: enzyme activator activity; G-protein-coupled receptor binding
Biological Process: lipid metabolic process; organ morphogenesis; respiratory gaseous exchange; sphingolipid metabolic process
Research Articles on Sftpb
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Diseases associated with Sftpb elisa kit
Organs/Tissues associated with Sftpb elisa kit
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