NP_001269792.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,972 Da
NCBI Official Full Name
R-spondin-2 isoform 2
NCBI Official Synonym Full Names
R-spondin 2
NCBI Official Synonym Symbols
NCBI Protein Information
R-spondin-2
UniProt Protein Name
R-spondin-2
UniProt Synonym Protein Names
Roof plate-specific spondin-2; hRspo2
UniProt Synonym Gene Names
NCBI Summary for RSPO2
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for RSPO2
R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component: cell surface; extracellular region
Molecular Function: heparin binding; protein binding; receptor binding
Biological Process: bone mineralization; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; osteoblast differentiation; positive regulation of Wnt receptor signaling pathway; Wnt signaling pathway
Research Articles on RSPO2
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Products associated with RSPO2 elisa kit
Diseases associated with RSPO2 elisa kit
Organs/Tissues associated with RSPO2 elisa kit
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