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ROCK1 elisa kit :: Mouse Rho-associated, coiled-coil containing protein kinase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9316713 ROCK1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rho-associated, coiled-coil containing protein kinase 1 (ROCK1), ELISA Kit

 Also Known As   

Mouse Rho-associated protein kinase 1, ROCK1 ELISA Kit

 Product Synonym Names    Mouse Rho-associated protein kinase 1 (ROCK1) ELISA kit; MGC131603; MGC43611; P160ROCK; PRO0435; Rho kinase; p160-ROCK; renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil containing protein kinase 1
 Product Gene Name   

ROCK1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 3D Structure    ModBase 3D Structure for P70335
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of ROCK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ROCK1 purchase    MBS9316713 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ROCK1. The ELISA analytical biochemical technique of the MBS9316713 kit is based on ROCK1 antibody-ROCK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ROCK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ROCK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ROCK1. It may not necessarily be applicable to this product.
 NCBI GI #    6677759
 NCBI GeneID    19877
 NCBI Accession #    NP_033097.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009071.2 [Other Products]
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 UniProt Primary Accession #    P70335 [Other Products]
 UniProt Secondary Accession #    Q8C3G4; Q8C7H0 [Other Products]
 UniProt Related Accession #    P70335 [Other Products]
 Molecular Weight    158,171 Da
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 NCBI Official Full Name    rho-associated protein kinase 1
 NCBI Official Synonym Full Names    Rho-associated coiled-coil containing protein kinase 1
 NCBI Official Symbol    Rock1 [Similar Products]
 NCBI Official Synonym Symbols   
Rock-I; 1110055K06Rik
[Similar Products]
 NCBI Protein Information    rho-associated protein kinase 1; p160ROCK; p160 ROCK-1; Rho-associated coiled-coil forming kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I
 UniProt Protein Name    Rho-associated protein kinase 1
 UniProt Synonym Protein Names   
Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
 Protein Family    Rho-associated protein kinase
 UniProt Gene Name    Rock1 [Similar Products]
 UniProt Synonym Gene Names    ROCK-I; p160ROCK [Similar Products]
 UniProt Entry Name    ROCK1_MOUSE
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 UniProt Comments for ROCK1    ROCK1: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Homodimer. Interacts with RHOB, RHOC, MYLC2B snd PTEN. Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner. Detected in blood platelets. Activated by RHOA binding. Inhibited by Y- 27632. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; ROCK subfamily

Cellular Component: ruffle; Golgi apparatus; cytoskeleton; cell projection; membrane; lamellipodium; cytoplasm; plasma membrane; intracellular

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; GTP-Rho binding; kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of actin filament-based process; apoptosis; cytoskeleton organization and biogenesis; bleb formation; signal transduction; protein amino acid phosphorylation; Rho protein signal transduction; leukocyte adhesion; negative regulation of angiogenesis; positive regulation of focal adhesion formation; regulation of stress fiber formation; membrane to membrane docking; myoblast migration; negative regulation of neuron apoptosis; leukocyte tethering or rolling; actin cytoskeleton organization and biogenesis; regulation of keratinocyte differentiation; phosphorylation; leukocyte migration; regulation of cytoskeleton organization and biogenesis
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 Research Articles on ROCK1    1. Activation of RhoA/ROCK1 by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1, which can be corrected by simvastatin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ROCK1 elisa kitPathways associated with ROCK1 elisa kit
 Reference Product  PubMed Publications
 Rhoa elisa kit  >85 publications with ROCK1 and Rhoa
 Rnd3 elisa kit  >7 publications with ROCK1 and Rnd3
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with ROCK1 elisa kitOrgans/Tissues associated with ROCK1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >52 publications with ROCK1 and Neoplasms
 Disease Models, Animal Antibodies  >32 publications with ROCK1 and Disease Models, Animal
 Vascular Diseases Antibodies  >28 publications with ROCK1 and Vascular Diseases
 Hypertension Antibodies  >24 publications with ROCK1 and Hypertension
 Heart Diseases Antibodies  >21 publications with ROCK1 and Heart Diseases
 Inflammation Antibodies  >19 publications with ROCK1 and Inflammation
 Fibrosis Antibodies  >17 publications with ROCK1 and Fibrosis
 Carcinoma Antibodies  >16 publications with ROCK1 and Carcinoma
 Neoplasm Metastasis Antibodies  >16 publications with ROCK1 and Neoplasm Metastasis
 Diabetes Mellitus Antibodies  >14 publications with ROCK1 and Diabetes Mellitus
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >51 publications with ROCK1 and Blood
 Heart Antibodies  >29 publications with ROCK1 and Heart
 Lung Antibodies  >18 publications with ROCK1 and Lung
 Brain Antibodies  >15 publications with ROCK1 and Brain
 Kidney Antibodies  >14 publications with ROCK1 and Kidney
 Bone Antibodies  >12 publications with ROCK1 and Bone
 Embryonic Tissue Antibodies  >11 publications with ROCK1 and Embryonic Tissue
 Prostate Antibodies  >8 publications with ROCK1 and Prostate
 Liver Antibodies  >7 publications with ROCK1 and Liver
 Eye Antibodies  >6 publications with ROCK1 and Eye
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