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S1PR1 elisa kit :: Mouse S1PR1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2516202
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S1PR1, ELISA Kit

★Popular Item★
 Also Known As   

Mouse S1PR1(Sphingosine 1 Phosphate Receptor 1)ELISA Kit

 Product Gene Name   

S1PR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601974
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 Species Reactivity    Mouse
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 Specificity    This kit recognizes natural and recombinantMouseS1PR1. No significant cross-reactivity or interference between MouseS1PR1 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of S1PR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for S1PR1 purchase    MBS2516202 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the S1PR1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing S1PR1, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2516202 kit is based on S1PR1 antibody-S1PR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect S1PR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, S1PR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for S1PR1 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of MouseS1PR1concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to S1PR1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for S1PR1and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain S1PR1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of S1PR1.You can calculate the concentration of S1PR1in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of S1PR1 elisa kit    S1PR1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2516202. Click to request current manual
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NCBI/Uniprot data below describe general gene information for S1PR1. It may not necessarily be applicable to this product.
 NCBI GI #    13027636
 NCBI GeneID    1901
 NCBI Accession #    NP_001391.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001400.4 [Other Products]
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 UniProt Secondary Accession #    Q9BYY4; Q9NYN8; D3DT66 [Other Products]
 UniProt Related Accession #    P21453 [Other Products]
 Molecular Weight    42,811 Da
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 NCBI Official Full Name    sphingosine 1-phosphate receptor 1
 NCBI Official Synonym Full Names    sphingosine-1-phosphate receptor 1
 NCBI Official Symbol    S1PR1 [Similar Products]
 NCBI Official Synonym Symbols   
EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
[Similar Products]
 NCBI Protein Information    sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1
 UniProt Protein Name    Sphingosine 1-phosphate receptor 1
 UniProt Synonym Protein Names   
Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363
 Protein Family    Sphingosine 1-phosphate receptor
 UniProt Gene Name    S1PR1 [Similar Products]
 UniProt Synonym Gene Names    CHEDG1; EDG1; S1P receptor 1; S1P1; S1P receptor Edg-1 [Similar Products]
 UniProt Entry Name    S1PR1_HUMAN
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 NCBI Summary for S1PR1    The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S1PR1    EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: integral to membrane; plasma membrane; intrinsic to plasma membrane; endosome; external side of plasma membrane; lipid raft

Molecular Function: G-protein coupled receptor activity; sphingolipid binding; G-protein-coupled receptor binding

Biological Process: lamellipodium biogenesis; regulation of cell adhesion; endothelial cell differentiation; cell migration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of bone resorption; positive regulation of positive chemotaxis; negative regulation of stress fiber formation; positive regulation of smooth muscle cell proliferation; transmission of nerve impulse; chemotaxis; blood vessel maturation; neuron differentiation; G-protein coupled receptor protein signaling pathway; actin cytoskeleton reorganization; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, adenylate cyclase inhibiting pathway; brain development; angiogenesis; cell adhesion; regulation of bone mineralization; positive regulation of cell migration
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 Research Articles on S1PR1    1. Study demonstrates a stark contrast between the consequences of S1PR1 signaling in Treg cells in the periphery versus tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with S1PR1 elisa kitPathways associated with S1PR1 elisa kit
 Reference Product  PubMed Publications
 RAC1 elisa kit  >10 publications with S1PR1 and RAC1
 CCR7 elisa kit  >6 publications with S1PR1 and CCR7
 AKT1 elisa kit  >3 publications with S1PR1 and AKT1
 PDGFRB elisa kit  >3 publications with S1PR1 and PDGFRB
 CCL21 elisa kit  >2 publications with S1PR1 and CCL21
 SRC elisa kit  >2 publications with S1PR1 and SRC
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
Diseases associated with S1PR1 elisa kitOrgans/Tissues associated with S1PR1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with S1PR1 and Inflammation
 Immune System Diseases Antibodies  >25 publications with S1PR1 and Immune System Diseases
 Necrosis Antibodies  >13 publications with S1PR1 and Necrosis
 Brain Diseases Antibodies  >10 publications with S1PR1 and Brain Diseases
 Edema Antibodies  >9 publications with S1PR1 and Edema
 Carcinoma Antibodies  >8 publications with S1PR1 and Carcinoma
 Liver Diseases Antibodies  >7 publications with S1PR1 and Liver Diseases
 Fibrosis Antibodies  >7 publications with S1PR1 and Fibrosis
 Adenocarcinoma Antibodies  >6 publications with S1PR1 and Adenocarcinoma
 Kidney Diseases Antibodies  >5 publications with S1PR1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with S1PR1 and Blood
 Vascular Antibodies  >44 publications with S1PR1 and Vascular
 Lymph Node Antibodies  >23 publications with S1PR1 and Lymph Node
 Lung Antibodies  >21 publications with S1PR1 and Lung
 Bone Marrow Antibodies  >16 publications with S1PR1 and Bone Marrow
 Brain Antibodies  >15 publications with S1PR1 and Brain
 Liver Antibodies  >13 publications with S1PR1 and Liver
 Muscle Antibodies  >12 publications with S1PR1 and Muscle
 Spleen Antibodies  >11 publications with S1PR1 and Spleen
 Embryonic Tissue Antibodies  >11 publications with S1PR1 and Embryonic Tissue
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