NP_001159687.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,279 Da
NCBI Official Full Name
sphingosine 1-phosphate receptor 5
NCBI Official Synonym Full Names
sphingosine-1-phosphate receptor 5
NCBI Official Synonym Symbols
EDG8; S1P5; Edg-8; SPPR-1; SPPR-2 [Similar Products]
NCBI Protein Information
sphingosine 1-phosphate receptor 5; S1P receptor 5; S1P receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-phosphate receptor Edg-8
UniProt Protein Name
Sphingosine 1-phosphate receptor 5
UniProt Synonym Protein Names
Endothelial differentiation G-protein-coupled receptor 8; Sphingosine 1-phosphate receptor Edg-8; S1P receptor Edg-8
UniProt Synonym Gene Names
UniProt Entry Name
S1PR5_HUMAN
NCBI Summary for S1PR5
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
UniProt Comments for S1PR5
EDG8: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: integral to membrane; plasma membrane
Biological Process: regulation of neuron differentiation
Research Articles on S1PR5
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Products associated with S1PR5 elisa kit
Pathways associated with S1PR5 elisa kit
Diseases associated with S1PR5 elisa kit
Organs/Tissues associated with S1PR5 elisa kit
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