NP_001034179.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,359 Da
NCBI Official Full Name
ski-like protein isoform b
NCBI Official Synonym Full Names
SKI-like
NCBI Protein Information
ski-like protein; ski/sno related; ski-related oncogene
UniProt Protein Name
Ski-like protein
UniProt Synonym Protein Names
Ski-related oncogene; Ski-related protein
UniProt Synonym Gene Names
UniProt Entry Name
SKIL_MOUSE
NCBI Summary for SKIL
This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for SKIL
SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing.
Cellular Component: PML body; protein complex; cytoplasm; acrosome; nucleus
Molecular Function: protein domain specific binding; protein binding; protein complex binding; chromatin binding; SMAD binding; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell differentiation; skeletal muscle development; transforming growth factor beta receptor signaling pathway; positive regulation of axonogenesis; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; lymphocyte homeostasis
Research Articles on SKIL
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with SKIL elisa kit
Diseases associated with SKIL elisa kit
Organs/Tissues associated with SKIL elisa kit
|