NP_001074480.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,798 Da
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 2
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 2
NCBI Official Synonym Symbols
FBP2; Fnbp2; srGAP3; AI448945; 9930124L22Rik [Similar Products]
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 2; FBP-27; formin binding protein 2; formin-binding protein 2; formin-binding protein 27
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 2
UniProt Synonym Protein Names
Formin-binding protein 2; Formin-binding protein 27; FBP-27
UniProt Synonym Gene Names
UniProt Entry Name
SRGP2_MOUSE
UniProt Comments for SRGAP2
SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
Protein type: GAPs, Rac/Rho; GAPs; Mitochondrial; Motility/polarity/chemotaxis
Cellular Component: postsynaptic density; phagocytic vesicle; cytosol; postsynaptic membrane; cell projection; membrane; lamellipodium; cytoplasm; mitochondrial inner membrane; plasma membrane; synapse; cytoplasmic vesicle; intracellular; cell junction; nucleus
Molecular Function: protein binding; protein homodimerization activity; Rac GTPase binding; GTPase activator activity
Biological Process: actin filament severing; nervous system development; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; signal transduction; negative regulation of cell migration; neurite morphogenesis; positive regulation of GTPase activity
Research Articles on SRGAP2
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Pathways associated with SRGAP2 elisa kit
Diseases associated with SRGAP2 elisa kit
Organs/Tissues associated with SRGAP2 elisa kit
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