NP_149409.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,407 Da
NCBI Official Full Name
SNRPN upstream reading frame protein
NCBI Official Synonym Full Names
SNRPN upstream reading frame
NCBI Protein Information
SNRPN upstream reading frame protein; small nuclear ribonucleoprotein N
UniProt Protein Name
SNRPN upstream reading frame protein
UniProt Entry Name
SNURF_MOUSE
NCBI Summary for SNURF
This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N (Snrpn). The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region in human and mouse is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known. [provided by RefSeq, Jul 2008]
UniProt Comments for SNURF
SNURF: a highly basic 71-aa nuclear protein. Encoded with SNRPN on a polycistronic transcript. Play an important role in maintaining differentialy methylated DNA. The gene is imprinted, and disruption of imprinting plays a role in Prader-Willi syndrome (PWS). Translated in normal, but not PWS, human, and mouse tissues.
Protein type: Transcription regulation; Gene silencing
Cellular Component: nucleus
Molecular Function: ATPase binding
Research Articles on SNURF
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Diseases associated with SNURF elisa kit
Organs/Tissues associated with SNURF elisa kit
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