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SOST elisa kit :: Mouse SOST ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2515625
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOST, ELISA Kit

★Popular Item★
 Also Known As   

Mouse SOST (Sclerostin) ELISA Kit

 Product Gene Name   

SOST elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    122860
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 Species Reactivity    Mouse
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 Specificity    This kit recognizes natural and recombinantMouseSOST. No significant cross-reactivity or interference between MouseSOST and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    15.625-1000pg/mL
 Sensitivity    Min: 9.375pg/mL; Max: 1000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SOST elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SOST purchase    MBS2515625 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SOST, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.625-1000pg/mL in biological research samples containing SOST, with an estimated sensitivity of Min: 9.375pg/mL; Max: 1000pg/mL. The ELISA analytical biochemical technique of the MBS2515625 kit is based on SOST antibody-SOST antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SOST antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SOST. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SOST elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of MouseSOSTconcentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to SOST. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for SOSTand Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain SOST, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of SOST.You can calculate the concentration of SOSTin the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of SOST elisa kit    SOST elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2515625. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SOST. It may not necessarily be applicable to this product.
 NCBI GI #    13376846
 NCBI GeneID    50964
 NCBI Accession #    NP_079513.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_025237.2 [Other Products]
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 UniProt Secondary Accession #    Q495N9 [Other Products]
 UniProt Related Accession #    Q9BQB4 [Other Products]
 Molecular Weight    24,264 Da
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 NCBI Official Full Name    sclerostin
 NCBI Official Synonym Full Names    sclerostin
 NCBI Official Symbol    SOST [Similar Products]
 NCBI Official Synonym Symbols   
CDD; VBCH; SOST1
[Similar Products]
 NCBI Protein Information    sclerostin
 UniProt Protein Name    Sclerostin
 Protein Family    Sclerostin
 UniProt Gene Name    SOST [Similar Products]
 UniProt Entry Name    SOST_HUMAN
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 NCBI Summary for SOST    Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOST    SOST: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Defects in SOST are the cause of sclerosteosis type 1 (SOST1). An autosomal recessive sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients. Defects in SOST are a cause of van Buchem disease (VBCH). An autosomal recessive sclerosing bone dysplasia characterized by endosteal hyperostosis of the mandible, skull, ribs, clavicles, and diaphyses of the long bones. Affected patients present a symmetrically increased thickness of bones, most frequently found as an enlarged jawbone, but also an enlargement of the skull, ribs, diaphysis of long bones, as well as tubular bones of hands and feet. The clinical consequence of increased thickness of the skull include facial nerve palsy causing hearing loss, visual problems, neurological pain, and, very rarely, blindness as a consequence of optic atrophy. Serum alkaline phosphatase levels are elevated. A 52 kb deletion downstream of SOST results in SOST transcription suppression causing van Buchem disease. Defects in SOST are a cause of craniodiaphyseal dysplasia autosomal dominant (CDD). A severe bone dysplasia characterized by massive generalized hyperostosis and sclerosis, especially involving the skull and facial bones. The sclerosis is so severe that the resulting facial distortion is referred to as 'leontiasis ossea' (leonine faces) and the bone deposition results in progressive stenosis of craniofacial foramina. Respiratory obstruction due to choanal stenosis compromises the clinical outcomes of affected patients. Heterozygous mutations located in the secretion signal of the SOST gene prevent sclerostin secretion and can be responsible for craniodiaphyseal dysplasia. Belongs to the sclerostin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: extracellular matrix; Golgi apparatus; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: heparin binding; protein binding; transcription factor binding

Biological Process: ossification; Wnt receptor signaling pathway; response to mechanical stimulus; positive regulation of transcription, DNA-dependent; negative regulation of ossification; negative regulation of protein complex assembly; negative regulation of BMP signaling pathway

Disease: Sclerosteosis 1; Hyperostosis Corticalis Generalisata; Craniodiaphyseal Dysplasia, Autosomal Dominant
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 Research Articles on SOST    1. This is the first study that shows that serum sclerostin values are associated, even after multiple adjustments, with fatal and nonfatal cardiovascular events in a nondialyzed kidney disease population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOST elisa kitPathways associated with SOST elisa kit
 Reference Product  PubMed Publications
 PTH elisa kit  >88 publications with SOST and PTH
 LRP5 elisa kit  >77 publications with SOST and LRP5
 LRP6 elisa kit  >28 publications with SOST and LRP6
 LRP4 elisa kit  >17 publications with SOST and LRP4
 WNT3A elisa kit  >15 publications with SOST and WNT3A
 BMP2 elisa kit  >12 publications with SOST and BMP2
 BMP6 elisa kit  >8 publications with SOST and BMP6
 SP7 elisa kit  >6 publications with SOST and SP7
 BMP5 elisa kit  >1 publications with SOST and BMP5
 NOG elisa kit  >1 publications with SOST and NOG
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
Diseases associated with SOST elisa kitOrgans/Tissues associated with SOST elisa kit
 Disease Name  Pubmed Publications
 Sclerosteosis Antibodies  >70 publications with SOST and Sclerosteosis
 Disease Models, Animal Antibodies  >36 publications with SOST and Disease Models, Animal
 Osteochondrodysplasias Antibodies  >32 publications with SOST and Osteochondrodysplasias
 Inflammation Antibodies  >20 publications with SOST and Inflammation
 Necrosis Antibodies  >17 publications with SOST and Necrosis
 Renal Insufficiency Antibodies  >16 publications with SOST and Renal Insufficiency
 Nervous System Diseases Antibodies  >15 publications with SOST and Nervous System Diseases
 Congenital Abnormalities Antibodies  >15 publications with SOST and Congenital Abnormalities
 Growth Disorders Antibodies  >10 publications with SOST and Growth Disorders
 Weight Loss Antibodies  >8 publications with SOST and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >592 publications with SOST and Bone
 Kidney Antibodies  >32 publications with SOST and Kidney
 Vascular Antibodies  >19 publications with SOST and Vascular
 Embryonic Tissue Antibodies  >14 publications with SOST and Embryonic Tissue
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