NP_038626.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,614 Da
NCBI Official Full Name
kit ligand isoform 1
NCBI Official Synonym Full Names
kit ligand
NCBI Official Synonym Symbols
Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted [Similar Products]
NCBI Protein Information
kit ligand
UniProt Protein Name
Kit ligand
UniProt Synonym Protein Names
Hematopoietic growth factor KL; Mast cell growth factor; MGF
UniProt Synonym Gene Names
UniProt Comments for SCF
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
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Pathways associated with SCF elisa kit
Diseases associated with SCF elisa kit
Organs/Tissues associated with SCF elisa kit
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