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TLR9 elisa kit :: Mouse TLR9 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2509526
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR9, ELISA Kit

★Popular Item★
 Also Known As   

Mouse TLR9 (Toll-like Receptor 9) ELISA Kit

 Product Gene Name   

TLR9 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605474
 3D Structure    ModBase 3D Structure for Q9NR96
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse TLR9. No significant cross-reactivity or interference between Mouse TLR9 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse TLR9 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156--10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TLR9 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TLR9 purchase    MBS2509526 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TLR9, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156--10ng/mL in biological research samples containing TLR9, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2509526 kit is based on TLR9 antibody-TLR9 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TLR9 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TLR9. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TLR9 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of TLR9 in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse TLR9. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse TLR9 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse TLR9, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse TLR9. You can calculate the concentration of Mouse TLR9 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TLR9 elisa kit    TLR9 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2509526. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TLR9. It may not necessarily be applicable to this product.
 NCBI GI #    8394456
 NCBI GeneID    54106
 NCBI Accession #    NP_059138.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017442.3 [Other Products]
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 UniProt Primary Accession #    Q9NR96 [Other Products]
 UniProt Secondary Accession #    Q6UVZ2; Q9HD68; Q9HD69; Q9HD70; Q9NYC2; Q9NYC3; B3Y661; D1CS56 [Other Products]
 UniProt Related Accession #    Q9NR96 [Other Products]
 Molecular Weight    114,237 Da
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 NCBI Official Full Name    toll-like receptor 9
 NCBI Official Synonym Full Names    toll-like receptor 9
 NCBI Official Symbol    TLR9 [Similar Products]
 NCBI Official Synonym Symbols   
CD289
[Similar Products]
 NCBI Protein Information    toll-like receptor 9
 UniProt Protein Name    Toll-like receptor 9
 UniProt Synonym Protein Names   
CD_antigen: CD289
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR9 [Similar Products]
 UniProt Entry Name    TLR9_HUMAN
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 NCBI Summary for TLR9    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR9    TLR9: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. Belongs to the Toll-like receptor family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; basolateral plasma membrane; lysosome; endoplasmic reticulum; cytoplasm; apical plasma membrane; integral to membrane; extracellular region; plasma membrane; endosome membrane; endosome

Molecular Function: siRNA binding; interleukin-1 receptor binding; transmembrane receptor activity

Biological Process: positive regulation of JNK activity; regulation of cytokine secretion; positive regulation of interleukin-12 production; maintenance of gastrointestinal epithelium; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; positive regulation of interleukin-18 production; defense response to Gram-negative bacterium; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to molecule of bacterial origin; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; positive regulation of interferon-beta production; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; positive regulation of interferon-beta biosynthetic process; defense response to bacterium; toll-like receptor signaling pathway; negative regulation of toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process
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 Research Articles on TLR9    1. Analysis of mRNA expression revealed significantly elevated levels of mRNA encoding TLR2 (P = 0.0006) and TLR4 (P = 0.0084) in pretreatment splenic aspirate samples from patients with visceral leishmaniasis, compared to post-treatment samples, but no change in expression of TLR9 (P = 0.43)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TLR9 elisa kitPathways associated with TLR9 elisa kit
 Reference Product  PubMed Publications
 TLR7 elisa kit  >748 publications with TLR9 and TLR7
 TLR3 elisa kit  >576 publications with TLR9 and TLR3
 MYD88 elisa kit  >469 publications with TLR9 and MYD88
 CD40 elisa kit  >165 publications with TLR9 and CD40
 CD86 elisa kit  >125 publications with TLR9 and CD86
 CTSB elisa kit  >2 publications with TLR9 and CTSB
 HSP90B1 elisa kit  >2 publications with TLR9 and HSP90B1
 CTSK elisa kit  >1 publications with TLR9 and CTSK
 CNPY3 elisa kit  >1 publications with TLR9 and CNPY3
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
Diseases associated with TLR9 elisa kitOrgans/Tissues associated with TLR9 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >649 publications with TLR9 and Inflammation
 Necrosis Antibodies  >430 publications with TLR9 and Necrosis
 Disease Models, Animal Antibodies  >248 publications with TLR9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >124 publications with TLR9 and Nervous System Diseases
 Hepatitis Antibodies  >96 publications with TLR9 and Hepatitis
 Kidney Diseases Antibodies  >72 publications with TLR9 and Kidney Diseases
 Brain Diseases Antibodies  >67 publications with TLR9 and Brain Diseases
 Lung Neoplasms Antibodies  >42 publications with TLR9 and Lung Neoplasms
 Heart Diseases Antibodies  >35 publications with TLR9 and Heart Diseases
 Fever Antibodies  >25 publications with TLR9 and Fever
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1517 publications with TLR9 and Blood
 Lymph Node Antibodies  >119 publications with TLR9 and Lymph Node
 Lymph Antibodies  >108 publications with TLR9 and Lymph
 Thymus Antibodies  >19 publications with TLR9 and Thymus
 Tonsil Antibodies  >17 publications with TLR9 and Tonsil
 Trachea Antibodies  >6 publications with TLR9 and Trachea
 Thyroid Antibodies  >3 publications with TLR9 and Thyroid
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