NP_000540.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,624 Da
NCBI Official Full Name
thyrotropin subunit beta isoform 1
NCBI Official Synonym Full Names
thyroid stimulating hormone beta
NCBI Protein Information
thyrotropin subunit beta
UniProt Protein Name
Thyrotropin subunit beta
UniProt Synonym Protein Names
Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa
UniProt Synonym Gene Names
UniProt Entry Name
TSHB_HUMAN
NCBI Summary for Tshbeta
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Comments for Tshbeta
TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p13
Cellular Component: cytoplasm; extracellular region
Molecular Function: hormone activity
Biological Process: anatomical structure morphogenesis; cell-cell signaling; cellular protein metabolic process; G-protein coupled receptor protein signaling pathway; peptide hormone processing; response to calcium ion; response to estrogen stimulus; response to vitamin A
Disease: Hypothyroidism, Congenital, Nongoitrous, 4
Research Articles on Tshbeta
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Products associated with Tshbeta elisa kit
Pathways associated with Tshbeta elisa kit
Diseases associated with Tshbeta elisa kit
Organs/Tissues associated with Tshbeta elisa kit
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