O43763.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,251 Da
NCBI Official Full Name
T-cell leukemia homeobox protein 2
NCBI Official Synonym Full Names
T-cell leukemia homeobox 2
NCBI Official Synonym Symbols
NCBI Protein Information
T-cell leukemia homeobox protein 2; homeo box 11-like 1; homeobox protein Hox-11L1; neural crest homeobox protein
UniProt Protein Name
T-cell leukemia homeobox protein 2
UniProt Synonym Protein Names
Homeobox protein Hox-11L1; Neural crest homeobox protein
UniProt Synonym Gene Names
UniProt Entry Name
TLX2_HUMAN
NCBI Summary for TPG
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
UniProt Comments for TPG
TLX2: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.
Protein type: Transcription factor; Cell development/differentiation; DNA-binding
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: cytoplasm; nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: mesoderm formation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of dendrite morphogenesis; enteric nervous system development
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Products associated with TPG elisa kit
Pathways associated with TPG elisa kit
Diseases associated with TPG elisa kit
Organs/Tissues associated with TPG elisa kit
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