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VE-Cadherin elisa kit :: Mouse VE-Cadherin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2514710 (SPECIAL PROMOTIONAL PRICING for a limited time)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $310 +1 FREE 8GB USB
96-Strip-Wells  /  $355 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,435 +1 FREE 8GB USB
10x96-Strip-Wells  /  $2,805 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VE-Cadherin, ELISA Kit

★Popular Item★
 Also Known As   

Mouse VE-Cadherin (Vascular Endothelial Cadherin) ELISA Kit

 Product Gene Name   

VE-Cadherin elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601120
 3D Structure    ModBase 3D Structure for P33151
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse VE-Cadherin. No significant cross-reactivity or interference between Mouse VE-Cadherin and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse VE-Cadherin and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156--10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VE-Cadherin elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VE-Cadherin purchase    MBS2514710 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the VE-Cadherin, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156--10ng/mL in biological research samples containing VE-Cadherin, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2514710 kit is based on VE-Cadherin antibody-VE-Cadherin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VE-Cadherin antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VE-Cadherin. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for VE-Cadherin elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of VE-Cadherin in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse VE-Cadherin. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse VE-Cadherin and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse VE-Cadherin, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse VE-Cadherin. You can calculate the concentration of Mouse VE-Cadherin in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of VE-Cadherin elisa kit    VE-Cadherin elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2514710. Click to request current manual
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NCBI/Uniprot data below describe general gene information for VE-Cadherin. It may not necessarily be applicable to this product.
 NCBI GI #    599834
 NCBI GeneID    1003
 NCBI Accession #    CAA56306.1 [Other Products]
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 UniProt Primary Accession #    P33151 [Other Products]
 UniProt Secondary Accession #    Q4VAI5; Q4VAI6 [Other Products]
 UniProt Related Accession #    P33151 [Other Products]
 Molecular Weight    74,499 Da
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 NCBI Official Full Name    VE-cadherin
 NCBI Official Synonym Full Names    cadherin 5, type 2 (vascular endothelium)
 NCBI Official Symbol    CDH5 [Similar Products]
 NCBI Official Synonym Symbols   
7B4; CD144
[Similar Products]
 NCBI Protein Information    cadherin-5; 7B4 antigen; VE-cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium); cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin
 UniProt Protein Name    Cadherin-5
 UniProt Synonym Protein Names   
7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD_antigen: CD144
 UniProt Gene Name    CDH5 [Similar Products]
 UniProt Synonym Gene Names    VE-cadherin [Similar Products]
 UniProt Entry Name    CADH5_HUMAN
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 NCBI Summary for VE-Cadherin    This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VE-Cadherin    CDH5: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: tight junction; adherens junction; membrane; integral to membrane; plasma membrane; intercellular junction; cell junction

Molecular Function: protein binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; receptor binding

Biological Process: negative regulation of cell proliferation; intercellular junction assembly and maintenance; vascular endothelial growth factor receptor signaling pathway; homophilic cell adhesion; blood vessel maturation
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 Research Articles on VE-Cadherin    1. N-cadherin is required to maintain the expression of VE-cadherin in malignant tumor cells but not vice versa. Thus, N-cadherin acts in concert with VE-cadherin to promote tumor growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VE-Cadherin elisa kitPathways associated with VE-Cadherin elisa kit
 Reference Product  PubMed Publications
 KDR elisa kit  >4 publications with VE-Cadherin and KDR
 VEGFA elisa kit  >2 publications with VE-Cadherin and VEGFA
 CTNNB1 elisa kit  >2 publications with VE-Cadherin and CTNNB1
 CTNNA1 elisa kit  >1 publications with VE-Cadherin and CTNNA1
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 S1P2 Pathway antibodies  S1P2 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with VE-Cadherin elisa kitOrgans/Tissues associated with VE-Cadherin elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with VE-Cadherin and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with VE-Cadherin and Inflammation
 Breast Neoplasms Antibodies  >4 publications with VE-Cadherin and Breast Neoplasms
 Hemorrhage Antibodies  >2 publications with VE-Cadherin and Hemorrhage
 Lung Diseases Antibodies  >2 publications with VE-Cadherin and Lung Diseases
 Necrosis Antibodies  >2 publications with VE-Cadherin and Necrosis
 Heart Diseases Antibodies  >2 publications with VE-Cadherin and Heart Diseases
 Atherosclerosis Antibodies  >2 publications with VE-Cadherin and Atherosclerosis
 Colorectal Neoplasms Antibodies  >2 publications with VE-Cadherin and Colorectal Neoplasms
 Myocardial Infarction Antibodies  >2 publications with VE-Cadherin and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >29 publications with VE-Cadherin and Vascular
 Embryonic Tissue Antibodies  >10 publications with VE-Cadherin and Embryonic Tissue
 Bone Antibodies  >6 publications with VE-Cadherin and Bone
 Brain Antibodies  >6 publications with VE-Cadherin and Brain
 Muscle Antibodies  >4 publications with VE-Cadherin and Muscle
 Heart Antibodies  >4 publications with VE-Cadherin and Heart
 Umbilical Cord Antibodies  >4 publications with VE-Cadherin and Umbilical Cord
 Kidney Antibodies  >4 publications with VE-Cadherin and Kidney
 Placenta Antibodies  >4 publications with VE-Cadherin and Placenta
 Lung Antibodies  >3 publications with VE-Cadherin and Lung
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