NP_033527.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,487 Da
NCBI Official Full Name
ventral anterior homeobox 1
NCBI Official Synonym Full Names
ventral anterior homeobox 1
NCBI Protein Information
ventral anterior homeobox 1; ventral anterior homeobox containing gene 1
UniProt Protein Name
Ventral anterior homeobox 1
UniProt Entry Name
VAX1_MOUSE
UniProt Comments for VAX1
VAX1: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk. Defects in VAX1 are the cause of microphthalmia, syndromic, type 11 (MCOPS11). A rare clinical entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum, hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Belongs to the EMX homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Cell development/differentiation; Motility/polarity/chemotaxis; DNA-binding
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; chromatin DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; axon guidance; nervous system development; camera-type eye development; central nervous system development; transcription, DNA-dependent; multicellular organismal development; neuron migration; negative regulation of transcription from RNA polymerase II promoter; palate development; regulation of transcription, DNA-dependent; negative regulation of neuroblast proliferation; brain development; cell differentiation
Research Articles on VAX1
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Diseases associated with VAX1 elisa kit
Organs/Tissues associated with VAX1 elisa kit
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