NP_084010.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
24,337 Da
NCBI Official Full Name
protein N-terminal glutamine amidohydrolase
NCBI Official Synonym Full Names
WDYHV motif containing 1
NCBI Official Synonym Symbols
Ntaq1; AU014961; AW550036; 2410187C16Rik [Similar Products]
NCBI Protein Information
protein N-terminal glutamine amidohydrolase; nt(Q)-amidase; N-terminal Gln amidase; WDYHV motif-containing protein 1; protein NH2-terminal glutamine deamidase
UniProt Protein Name
Protein N-terminal glutamine amidohydrolase
UniProt Synonym Protein Names
Protein NH2-terminal glutamine deamidase; N-terminal Gln amidase; Nt(Q)-amidase; WDYHV motif-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
NTAQ1_MOUSE
UniProt Comments for WDYHV1
WDYHV1: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Belongs to the NTAQ1 family.
Protein type: EC 3.5.1.-
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: N-acetylgalactosamine-6-phosphate deacetylase activity; (3,5-dichlorophenylurea)acetate amidohydrolase activity; N2-acetyl-L-lysine deacetylase activity; iprodione amidohydrolase activity; hydrolase activity; indoleacetamide hydrolase activity; protein N-terminal asparagine amidohydrolase activity; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; histone deacetylase activity; O-succinylbenzoate synthase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Biological Process: protein modification process; protein catabolic process
Research Articles on WDYHV1
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