NP_082288.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,061 Da
NCBI Official Full Name
DNA repair protein XRCC4
NCBI Official Synonym Full Names
X-ray repair complementing defective repair in Chinese hamster cells 4
NCBI Official Synonym Symbols
AW413319; AW545101; 2310057B22Rik [Similar Products]
NCBI Protein Information
DNA repair protein XRCC4; X-ray repair cross-complementing protein 4
UniProt Protein Name
DNA repair protein XRCC4
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 4
UniProt Entry Name
XRCC4_MOUSE
UniProt Comments for XRCC4
XRCC4: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Widely expressed. Belongs to the XRCC4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; DNA ligase IV complex; centrosome; DNA-dependent protein kinase complex; cytosol; cell junction; nucleus
Molecular Function: protein C-terminus binding; DNA binding
Biological Process: pro-B cell differentiation; positive regulation of neurogenesis; central nervous system development; V(D)J recombination; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; T cell differentiation in the thymus; DNA repair; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation; positive regulation of fibroblast proliferation; double-strand break repair; DNA ligation during DNA repair; response to gamma radiation; response to ionizing radiation; negative regulation of neuron apoptosis; positive regulation of ligase activity; response to DNA damage stimulus; response to X-ray
Research Articles on XRCC4
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Pathways associated with XRCC4 elisa kit
Diseases associated with XRCC4 elisa kit
Organs/Tissues associated with XRCC4 elisa kit
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