NP_001240608.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,677 Da
NCBI Official Full Name
Y+L amino acid transporter 1
NCBI Official Synonym Full Names
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
NCBI Protein Information
Y+L amino acid transporter 1
UniProt Protein Name
Y+L amino acid transporter 1
UniProt Synonym Protein Names
Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1
UniProt Synonym Gene Names
UniProt Comments for SLC7A7
SLC7A7: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. Defects in SLC7A7 are the cause of lysinuric protein intolerance (LPI). LPI is an autosomal recessive multisystem disorder found mainly in Finland and Italy. On a normal diet, LPI patients present poor feeding, vomiting, diarrhea, episodes of hyperammoniaemic coma and growth retardation. Hepatosplenomegaly, osteoporosis and a life- threatening pulmonary involvement (alveolar proteinosis) are also seen. Biochemically LPI is characterized by a defect in the plasma membrane transport of dibasic amino acids. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 14|14 C2
Cellular Component: integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; antiporter activity; basic amino acid transmembrane transporter activity; L-amino acid transmembrane transporter activity
Biological Process: amino acid transport; regulation of arginine metabolic process; transport
Research Articles on SLC7A7
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Pathways associated with SLC7A7 elisa kit
Diseases associated with SLC7A7 elisa kit
Organs/Tissues associated with SLC7A7 elisa kit
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