NP_001028772.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,077 Da
NCBI Official Full Name
long-chain-fatty-acid--CoA ligase 4 isoform 2
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 4
NCBI Official Synonym Symbols
ACS4; Facl4; Lacs4; AU018108; 9430020A05Rik [Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 4; mACS4; LACS 4; long-chain acyl-CoA synthetase 4; fatty acid-Coenzyme A ligase, long chain 4
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 4
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 4; LACS 4; mACS4
UniProt Synonym Gene Names
UniProt Entry Name
ACSL4_MOUSE
UniProt Comments for ACSL4
ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Lipid Metabolism - fatty acid; EC 6.2.1.3; Ligase
Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; membrane; cell soma; mitochondrion; endoplasmic reticulum; cytoplasm; mitochondrial membrane; integral to membrane; peroxisome; lipid particle
Molecular Function: nucleotide binding; arachidonate-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity; catalytic activity; ATP binding; ligase activity; long-chain-fatty-acid-CoA ligase activity
Biological Process: neuron differentiation; triacylglycerol metabolic process; metabolic process; regulation of fatty acid metabolic process; lipid biosynthetic process; embryonic process involved in female pregnancy; lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; negative regulation of prostaglandin secretion; positive regulation of cell growth; fatty acid transport
Research Articles on ACSL4
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Pathways associated with ACSL4 elisa kit
Diseases associated with ACSL4 elisa kit
Organs/Tissues associated with ACSL4 elisa kit
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