ACF25898.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,989 Da
NCBI Official Full Name
ALDH2, partial
NCBI Official Synonym Full Names
aldehyde dehydrogenase 2 family member
NCBI Protein Information
aldehyde dehydrogenase, mitochondrial
UniProt Protein Name
Aldehyde dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ALDH class 2; ALDH-E2; ALDHI
UniProt Synonym Gene Names
NCBI Summary for ALDH2
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
Research Articles on ALDH2
Precautions
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Disclaimer
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Products associated with ALDH2 elisa kit
Pathways associated with ALDH2 elisa kit
Diseases associated with ALDH2 elisa kit
Organs/Tissues associated with ALDH2 elisa kit
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