NP_062340.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
16,911 Da
NCBI Official Full Name
allograft inflammatory factor 1
NCBI Official Synonym Full Names
allograft inflammatory factor 1
NCBI Official Synonym Symbols
G1; Iba1; AIF-1; AI607846; D17H6S50E [Similar Products]
NCBI Protein Information
allograft inflammatory factor 1; testis specific; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1
UniProt Protein Name
Allograft inflammatory factor 1
UniProt Synonym Protein Names
Ionized calcium-binding adapter molecule 1
UniProt Synonym Gene Names
UniProt Entry Name
AIF1_MOUSE
UniProt Comments for AIF1
AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Cellular Component: actin filament; perikaryon; cytosol; ruffle; cell projection; cytoskeleton; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; nucleus; phagocytic cup
Molecular Function: actin filament binding; protein binding; metal ion binding; calcium ion binding; actin binding
Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; actin filament polymerization; positive regulation of smooth muscle cell proliferation; positive regulation of muscle hyperplasia; microglial cell activation; Rac protein signal transduction; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on AIF1
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Diseases associated with AIF1 elisa kit
Organs/Tissues associated with AIF1 elisa kit
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