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A2MP elisa kit :: Mouse alpha-2-macroglobulin pseudogene ELISA Kit

Scan QR to view Datasheet Catalog #    MBS923863 A2MP elisa kit
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha-2-macroglobulin pseudogene (A2MP), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Alpha-2-macroglobulin-P, A2MP ELISA Kit

 Product Synonym Names    Mouse Alpha-2-macroglobulin-P (A2MP) ELISA kit; alpha-2-macroglobulin pseudogene
 Product Gene Name   

A2MP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for Q6GQT1
 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse A2MP. No significant cross-reactivity or interference between mouse A2MP and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Quantitative Sandwich
 Detection Range    0.47 ug/ml -30 ug/ml
 Sensitivity    Typically less than 0.12 ug/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of A2MP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for A2MP purchase    MBS923863 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the alpha-2-macroglobulin pseudogene (A2MP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.47 ug/ml -30 ug/ml in biological research samples containing A2MP, with an estimated sensitivity of Typically less than 0.12 ug/ml. The ELISA analytical biochemical technique of the MBS923863 kit is based on A2MP antibody-A2MP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect A2MP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, A2MP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for A2MP elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for A2MP has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any A2MP present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for A2MP is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of A2MP bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS923863. Click to request current manual
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NCBI/Uniprot data below describe general gene information for A2MP. It may not necessarily be applicable to this product.
 NCBI GI #    148277039
 NCBI GeneID    232345
 NCBI Accession #    NP_783327.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_175628.3 [Other Products]
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 UniProt Primary Accession #    Q6GQT1 [Other Products]
 UniProt Secondary Accession #    Q811S0; E9QMQ7 [Other Products]
 UniProt Related Accession #    Q6GQT1 [Other Products]
 Molecular Weight    164,353 Da
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 NCBI Official Full Name    alpha-2-macroglobulin-P
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2m [Similar Products]
 NCBI Official Synonym Symbols   
A2mp
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin-P
 UniProt Protein Name    Alpha-2-macroglobulin-P
 UniProt Synonym Protein Names   
Alpha-2-macroglobulin
 UniProt Gene Name    A2mp [Similar Products]
 UniProt Synonym Gene Names    A2m [Similar Products]
 UniProt Entry Name    A2MP_MOUSE
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 UniProt Comments for A2MP    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; protease inhibitor activity; growth factor binding; endopeptidase inhibitor activity; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; negative regulation of peptidase activity; female pregnancy; stem cell differentiation
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 Research Articles on A2MP    1. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with A2MP elisa kitDiseases associated with A2MP elisa kit
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >86 publications with A2MP and Nervous System Diseases
 Brain Diseases Antibodies  >83 publications with A2MP and Brain Diseases
 Neurodegenerative Diseases Antibodies  >80 publications with A2MP and Neurodegenerative Diseases
 Mental Disorders Antibodies  >77 publications with A2MP and Mental Disorders
 Alzheimer Disease Antibodies  >75 publications with A2MP and Alzheimer Disease
 Neoplasms Antibodies  >30 publications with A2MP and Neoplasms
 Inflammation Antibodies  >25 publications with A2MP and Inflammation
 Cardiovascular Diseases Antibodies  >19 publications with A2MP and Cardiovascular Diseases
 Necrosis Antibodies  >13 publications with A2MP and Necrosis
 Hepatitis Antibodies  >11 publications with A2MP and Hepatitis
Organs/Tissues associated with A2MP elisa kit
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >78 publications with A2MP and Other
 Brain Antibodies  >27 publications with A2MP and Brain
 Lung Antibodies  >10 publications with A2MP and Lung
 Uterus Antibodies  >6 publications with A2MP and Uterus
 Embryonic Tissue Antibodies  >5 publications with A2MP and Embryonic Tissue
 Ovary Antibodies  >3 publications with A2MP and Ovary
 Testis Antibodies  >2 publications with A2MP and Testis
 Mammary Gland Antibodies  >1 publications with A2MP and Mammary Gland
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