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alpha-SYNo elisa kit :: Mouse alpha Synuclein oligomer ELISA Kit

Scan QR to view Datasheet Catalog #    MBS724099
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha Synuclein oligomer (alpha-SYNo), ELISA Kit

★Popular Item★
 Also Known As   

Mouse alpha Synuclein oligomer ELISA Kit

 Product Synonym Names    Mouse a Synuclein oligomer ELISA Kit
 Product Gene Name   

alpha-SYNo elisa kit

[Similar Products]
 Product Synonym Gene Name    a-SYNo [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605543
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of SNCOalpha. No significant cross-reactivity or interference between SNCOalpha and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between SNCOalpha and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Sandwich
 Detection Range    25-500pg/mL
 Sensitivity    1.0pg/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of alpha-SYNo elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for alpha-SYNo purchase    MBS724099 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the alpha Synuclein oligomer (alpha-SYNo) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 25-500pg/mL in biological research samples containing alpha-SYNo, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS724099 kit is based on alpha-SYNo antibody-alpha-SYNo antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect alpha-SYNo antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, alpha-SYNo. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for alpha-SYNo elisa kit

   Intended Uses: This SNCOalpha ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Mouse SNCOalpha. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Principle of the Assay: SNCOalpha ELISA kit applies the quantitative sandwich enzyme immunoassay technique. The microtiter plate has been pre-coated with a monoclonal antibody specific for SNCOalpha. Standards or samples are then added to the microtiter plate wells and SNCOalpha if present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of SNCOalpha present in the sample, a standardized preparation of horseradish peroxidase (HRP)-conjugated polyclonal antibody, specific for SNCOalpha are added to each well to "sandwich" the SNCOalpha immobilized on the plate. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, substrate solutions are added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period. Only those wells that contain SNCOalpha and enzyme-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The SNCOalpha concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for alpha-SYNo elisa kit    Neurobiology
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 Typical Testing Data/Standard Curve (for reference only) of alpha-SYNo elisa kit    alpha-SYNo elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS724099. Click to request current manual
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NCBI/Uniprot data below describe general gene information for alpha-SYNo. It may not necessarily be applicable to this product.
 NCBI GI #    586067
 NCBI GeneID    6622
 NCBI Accession #    P37840.1 [Other Products]
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 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da
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 NCBI Official Full Name    Alpha-synuclein
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for alpha-SYNo    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for alpha-SYNo    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; rough endoplasmic reticulum; mitochondrion; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; cytosol; mitochondrial respiratory chain complex I; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; cell junction; nucleus

Molecular Function: identical protein binding; protein domain specific binding; zinc ion binding; histone binding; kinesin binding; microtubule binding; ferrous iron binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; oxidoreductase activity; calcium ion binding; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; fatty acid binding; tau protein binding; alpha-tubulin binding

Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; positive regulation of apoptosis; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; synapse organization and biogenesis; fibril organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; negative regulation of monooxygenase activity; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of dopamine uptake; negative regulation of histone acetylation; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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 Research Articles on alpha-SYNo    1. SNCA may have a role in impulse control in humans
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with alpha-SYNo elisa kitPathways associated with alpha-SYNo elisa kit
 Reference Product  PubMed Publications
 PARK2 elisa kit  >901 publications with alpha-SYNo and PARK2
 LRRK2 elisa kit  >130 publications with alpha-SYNo and LRRK2
 PARK7 elisa kit  >53 publications with alpha-SYNo and PARK7
 SNCAIP elisa kit  >31 publications with alpha-SYNo and SNCAIP
 SLC6A3 elisa kit  >12 publications with alpha-SYNo and SLC6A3
 BAD elisa kit  >3 publications with alpha-SYNo and BAD
 FYN elisa kit  >2 publications with alpha-SYNo and FYN
 GRK5 elisa kit  >1 publications with alpha-SYNo and GRK5
 STUB1 elisa kit  >1 publications with alpha-SYNo and STUB1
 UBC elisa kit  >1 publications with alpha-SYNo and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with alpha-SYNo elisa kitOrgans/Tissues associated with alpha-SYNo elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1126 publications with alpha-SYNo and Nervous System Diseases
 Brain Diseases Antibodies  >1106 publications with alpha-SYNo and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1095 publications with alpha-SYNo and Neurodegenerative Diseases
 Movement Disorders Antibodies  >967 publications with alpha-SYNo and Movement Disorders
 Parkinsonian Disorders Antibodies  >896 publications with alpha-SYNo and Parkinsonian Disorders
 Parkinson Disease Antibodies  >843 publications with alpha-SYNo and Parkinson Disease
 Lewy Body Disease Antibodies  >278 publications with alpha-SYNo and Lewy Body Disease
 Nerve Degeneration Antibodies  >164 publications with alpha-SYNo and Nerve Degeneration
 Disease Models, Animal Antibodies  >140 publications with alpha-SYNo and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >56 publications with alpha-SYNo and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >999 publications with alpha-SYNo and Nerve
 Brain Antibodies  >773 publications with alpha-SYNo and Brain
 Blood Antibodies  >67 publications with alpha-SYNo and Blood
 Embryonic Tissue Antibodies  >28 publications with alpha-SYNo and Embryonic Tissue
 Kidney Antibodies  >19 publications with alpha-SYNo and Kidney
 Heart Antibodies  >10 publications with alpha-SYNo and Heart
 Eye Antibodies  >10 publications with alpha-SYNo and Eye
 Bone Antibodies  >8 publications with alpha-SYNo and Bone
 Vascular Antibodies  >7 publications with alpha-SYNo and Vascular
 Liver Antibodies  >7 publications with alpha-SYNo and Liver
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