NP_035916.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,473 Da
NCBI Official Full Name
hydroperoxide isomerase ALOXE3
NCBI Official Synonym Full Names
arachidonate lipoxygenase 3
NCBI Protein Information
hydroperoxide isomerase ALOXE3; epidermal LOX-3; epidermis-type lipoxygenase 3
UniProt Protein Name
Hydroperoxide isomerase ALOXE3
UniProt Synonym Protein Names
Epidermis-type lipoxygenase 3 (EC:1.13.11.-); Epidermal LOX-3; e-LOX-3; eLOX-3
UniProt Synonym Gene Names
UniProt Entry Name
LOXE3_MOUSE
UniProt Comments for ALOXE3
ALOXE3: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 5.4.4.7; Oxidoreductase; EC 4.2.1.152
Cellular Component: cytoplasm
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; hepoxilin A3 synthase activity; dioxygenase activity; iron ion binding; metal ion binding; lyase activity; isomerase activity; oxidoreductase activity; catalytic activity
Biological Process: fat cell differentiation; epidermis development; sphingolipid metabolic process; lipoxygenase pathway; linoleic acid metabolic process; ceramide biosynthetic process; arachidonic acid metabolic process; lipid metabolic process; hepoxilin biosynthetic process; fatty acid metabolic process; sensory perception of pain
Research Articles on ALOXE3
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Products associated with ALOXE3 elisa kit
Diseases associated with ALOXE3 elisa kit
Organs/Tissues associated with ALOXE3 elisa kit
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