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ATR elisa kit :: Mouse ataxia telangiectasia and Rad3 related ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9330850 ATR elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ataxia telangiectasia and Rad3 related (ATR), ELISA Kit

 Also Known As   

Mouse Serine/threonine-protein kinase ATR, ATR ELISA Kit

 Product Synonym Names    Mouse Serine/threonine-protein kinase ATR (ATR) ELISA kit; FRP1; MEC1; SCKL; SCKL1; FRAP-related protein-1; MEC1; mitosis entry checkpoint 1; homolog; Rad3 related protein; ataxia telangiectasia and Rad3 related protein; protein kinase ATR; ataxia telangiectasia and Rad3 related
 Product Gene Name   

ATR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 3D Structure    ModBase 3D Structure for Q9JKK8
 Species Reactivity    Mouse
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Quantitative Sandwich
 Detection Range    0.625ng/ml-20ng/ml
 Sensitivity    0.1ng/ml
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of ATR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATR purchase    MBS9330850 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ataxia telangiectasia and Rad3 related (ATR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625ng/ml-20ng/ml in biological research samples containing ATR, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS9330850 kit is based on ATR antibody-ATR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for ATR elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ATR (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9330850
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NCBI/Uniprot data below describe general gene information for ATR. It may not necessarily be applicable to this product.
 NCBI GI #    62286489
 NCBI GeneID    245000
 NCBI Accession #    Q9JKK8.2 [Other Products]
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 UniProt Primary Accession #    Q9JKK8 [Other Products]
 UniProt Secondary Accession #    Q3TBS8; Q3TNX3; Q3TZM6; Q3UT26; Q3V1V6; Q571L3 [Other Products]
 UniProt Related Accession #    Q9JKK8 [Other Products]
 Molecular Weight    300,224 Da
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 NCBI Official Full Name    Serine/threonine-protein kinase ATR
 NCBI Official Synonym Full Names    ataxia telangiectasia and Rad3 related
 NCBI Official Symbol    Atr [Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase ATR; ataxia telangiectasia and Rad3-related protein
 UniProt Protein Name    Serine/threonine-protein kinase ATR
 UniProt Synonym Protein Names   
Ataxia telangiectasia and Rad3-related protein
 UniProt Gene Name    Atr [Similar Products]
 UniProt Synonym Gene Names    Kiaa4069 [Similar Products]
 UniProt Entry Name    ATR_MOUSE
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 UniProt Comments for ATR    ATR: a ser/thr kinase of the PIKK family most closely related to ATM. Activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]Q. Phosphorylates BRCA1, Chk1, MCM2, RAD17, RPA2, SMC1 and p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Protein type: Kinase, lipid; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Protein kinase, atypical; EC 2.7.11.1; ATYPICAL group; PIKK family; ATR subfamily

Cellular Component: XY body; nucleoplasm; Golgi apparatus; PML body; chromosome; nucleus

Molecular Function: transferase activity; protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; MutLalpha complex binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; MutSalpha complex binding; ATP binding; protein kinase activity

Biological Process: peptidyl-serine phosphorylation; negative regulation of DNA replication; protein amino acid autophosphorylation; regulation of protein binding; DNA damage checkpoint; positive regulation of DNA damage response, signal transduction by p53 class mediator; DNA repair; response to DNA damage stimulus; phosphorylation; protein amino acid phosphorylation; double-strand break repair via homologous recombination
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 Research Articles on ATR    1. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ATR elisa kitOrgans/Tissues associated with ATR elisa kit
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >234 publications with ATR and Brain
 Skin Antibodies  >195 publications with ATR and Skin
 Bone Antibodies  >111 publications with ATR and Bone
 Heart Antibodies  >111 publications with ATR and Heart
 Eye Antibodies  >100 publications with ATR and Eye
 Lung Antibodies  >81 publications with ATR and Lung
 Liver Antibodies  >43 publications with ATR and Liver
 Embryonic Tissue Antibodies  >31 publications with ATR and Embryonic Tissue
 Bone Marrow Antibodies  >24 publications with ATR and Bone Marrow
 Testis Antibodies  >18 publications with ATR and Testis
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