NP_031526.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,854 Da
NCBI Official Full Name
protein atonal homolog 1
NCBI Official Synonym Full Names
atonal homolog 1 (Drosophila)
NCBI Protein Information
protein atonal homolog 1; helix-loop-helix protein mATH-1
UniProt Protein Name
Protein atonal homolog 1
UniProt Synonym Protein Names
Helix-loop-helix protein mATH-1; mATH1
UniProt Synonym Gene Names
UniProt Entry Name
ATOH1_MOUSE
UniProt Comments for ATOH1
ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.
Protein type: DNA-binding; Cell development/differentiation; Transcription factor
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding
Biological Process: transcription from RNA polymerase II promoter; axon guidance; nervous system development; inner ear morphogenesis; auditory receptor cell fate determination; transcription, DNA-dependent; regulation of neuron differentiation; multicellular organismal development; neuron migration; auditory receptor cell differentiation; neuron differentiation; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of auditory receptor cell differentiation; brain development; auditory receptor cell fate specification; positive regulation of neuron differentiation; cell differentiation; inner ear development; negative regulation of apoptosis
Research Articles on ATOH1
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Diseases associated with ATOH1 elisa kit
Organs/Tissues associated with ATOH1 elisa kit
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