NP_031737.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,869 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 3 isoform a
NCBI Official Synonym Full Names
chloride channel 3
NCBI Official Synonym Symbols
NCBI Protein Information
H(+)/Cl(-) exchange transporter 3; H(+)/Cl(-) exchange transporter 3; clC-3; chloride channel protein 3; chloride transporter ClC-3
UniProt Protein Name
H(+)/Cl(-) exchange transporter 3
UniProt Synonym Protein Names
Chloride channel protein 3; ClC-3; Chloride transporter ClC-3
UniProt Synonym Gene Names
UniProt Entry Name
CLCN3_MOUSE
UniProt Comments for CLCN3
CLCN3: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, multi-pass; Transporter; Membrane protein, integral; Vesicle; Channel, chloride
Cellular Component: Golgi apparatus; specific granule; cell; early endosome; integral to membrane; vesicle membrane; phagocytic vesicle; secretory granule; synaptic vesicle; membrane; apical plasma membrane; late endosome; plasma membrane; synapse; cytoplasmic vesicle; intracellular; nerve terminal; endosome; external side of plasma membrane
Molecular Function: chloride channel activity; protein heterodimerization activity; nucleotide binding; ion channel activity; voltage-gated chloride channel activity; voltage-gated ion channel activity; ATP binding; PDZ domain binding; antiporter activity
Biological Process: synaptic transmission, glutamatergic; adult locomotory behavior; transport; photoreceptor cell maintenance; synaptic transmission, GABAergic; ion transport; chloride transport; phagocytosis, engulfment; transmembrane transport; negative regulation of cell volume
Research Articles on CLCN3
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Diseases associated with CLCN3 elisa kit
Organs/Tissues associated with CLCN3 elisa kit
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