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CIITA elisa kit :: Mouse class II, major histocompatibility complex, transactivator ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9320921 CIITA elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

class II, major histocompatibility complex, transactivator (CIITA), ELISA Kit

★Popular Item★
 Also Known As   

Mouse MHC class II transactivator, CIITA ELISA Kit

 Product Synonym Names    Mouse MHC class II transactivator (CIITA) ELISA kit; C2TA; CIITAIV; MHC2TA; NLRA; MHC class II transactivator type III; NLR family; acid domain containing; class II transactivator; nucleotide-binding oligomerization domain; leucine rich repeat and acid d; class II; major histocompatibility complex; transactivator
 Product Gene Name   

CIITA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P79621
 Species Reactivity    Mouse
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.625 ng/ml - 20 ng/ml
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CIITA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CIITA purchase    MBS9320921 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the class II, major histocompatibility complex, transactivator (CIITA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing CIITA, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9320921 kit is based on CIITA antibody-CIITA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CIITA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CIITA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CIITA elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CIITA (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9320921. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CIITA. It may not necessarily be applicable to this product.
 NCBI GI #    344217728
 NCBI GeneID    12265
 NCBI Accession #    NP_001230690.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243761.1 [Other Products]
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 UniProt Primary Accession #    P79621 [Other Products]
 UniProt Secondary Accession #    O46787; O78036; O78109; Q31115; Q9TPP1 [Other Products]
 UniProt Related Accession #    P79621 [Other Products]
 Molecular Weight    127,528 Da
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 NCBI Official Full Name    MHC class II transactivator isoform 3
 NCBI Official Synonym Full Names    class II transactivator
 NCBI Official Symbol    Ciita [Similar Products]
 NCBI Official Synonym Symbols   
C2ta; Gm9475; EG669998
[Similar Products]
 NCBI Protein Information    MHC class II transactivator
 UniProt Protein Name    MHC class II transactivator
 Protein Family    MHC class II transactivator
 UniProt Gene Name    Ciita [Similar Products]
 UniProt Synonym Gene Names    C2ta; Mhc2ta; CIITA [Similar Products]
 UniProt Entry Name    C2TA_MOUSE
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 NCBI Summary for CIITA    This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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 UniProt Comments for CIITA    CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.

Protein type: Transcription, coactivator/corepressor; DNA-binding; EC 2.7.11.1

Cellular Component: PML body; cell surface; nucleus

Molecular Function: glucosaminyl-phosphotidylinositol O-acyltransferase activity; S-malonyltransferase activity; S-acetyltransferase activity; O-octanoyltransferase activity; O-sinapoyltransferase activity; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; peptidyl-lysine N6-myristoyltransferase activity; azetidine-2-carboxylic acid acetyltransferase activity; Ras palmitoyltransferase activity; palmitoyltransferase activity; protein complex binding; C-palmitoyltransferase activity; ATP binding; O-succinyltransferase activity; octanoyltransferase activity; malonyltransferase activity; sterol O-acyltransferase activity; nucleotide binding; O-acyltransferase activity; O-acetyltransferase activity; benzoyl acetate-CoA thiolase activity; transferase activity; sinapoyltransferase activity; S-acyltransferase activity; N-succinyltransferase activity; L-2-aminoadipate N-acetyltransferase activity; keto acid formate lyase activity; GTP binding; 3-hydroxybutyryl-CoA thiolase activity; acyl-CoA N-acyltransferase activity; peptidyl-lysine N6-palmitoyltransferase activity; dihydrolipoamide branched chain acyltransferase activity; succinyltransferase activity; C-acyltransferase activity; dihydrolipoamide S-acyltransferase activity; protein C-terminus binding; protein-cysteine S-acyltransferase activity; N-acetyltransferase activity; serine O-acyltransferase activity; transcription activator binding; O-palmitoyltransferase activity; 3-ketopimelyl-CoA thiolase activity; carnitine O-acyltransferase activity; S-succinyltransferase activity; N-acyltransferase activity; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity; N-palmitoyltransferase activity; acylglycerol O-acyltransferase activity; protein-cysteine S-myristoyltransferase activity; myristoyltransferase activity; acetyltransferase activity; transferase activity, transferring acyl groups; kinase activity

Biological Process: response to antibiotic; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation
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 Research Articles on CIITA    1. Data indicate that during Mycobacterium bovis BCG infection, iNOS/NO responsive KLF4 induces EZH2 and miR-150 functions to regulate CIITA expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CIITA elisa kitDiseases associated with CIITA elisa kit
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >130 publications with CIITA and Neoplasms
 Inflammation Antibodies  >45 publications with CIITA and Inflammation
 Carcinoma Antibodies  >34 publications with CIITA and Carcinoma
 Neoplasms, Experimental Antibodies  >29 publications with CIITA and Neoplasms, Experimental
 Necrosis Antibodies  >28 publications with CIITA and Necrosis
 Leukemia Antibodies  >18 publications with CIITA and Leukemia
 Arthritis, Rheumatoid Antibodies  >13 publications with CIITA and Arthritis, Rheumatoid
 Multiple Sclerosis Antibodies  >11 publications with CIITA and Multiple Sclerosis
 Cardiovascular Diseases Antibodies  >11 publications with CIITA and Cardiovascular Diseases
 Kidney Diseases Antibodies  >10 publications with CIITA and Kidney Diseases
Organs/Tissues associated with CIITA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >24 publications with CIITA and Lung
 Kidney Antibodies  >19 publications with CIITA and Kidney
 Spleen Antibodies  >17 publications with CIITA and Spleen
 Thymus Antibodies  >12 publications with CIITA and Thymus
 Skin Antibodies  >10 publications with CIITA and Skin
 Embryonic Tissue Antibodies  >10 publications with CIITA and Embryonic Tissue
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