NP_001273502.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
138,039 Da
NCBI Official Full Name
histone-lysine N-methyltransferase EHMT2 isoform c
NCBI Official Synonym Full Names
euchromatic histone lysine N-methyltransferase 2
NCBI Official Synonym Symbols
G9a; Bat8; NG36; KMT1C; D17Ertd710e [Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase EHMT2; protein G9a; H3-K9-HMTase 3; HLA-B associated transcript 8; HLA-B-associated transcript 8; histone H3-K9 methyltransferase 3; euchromatic histone-lysine N-methyltransferase 2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3
UniProt Protein Name
Histone-lysine N-methyltransferase EHMT2
UniProt Synonym Protein Names
Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Protein G9a
UniProt Synonym Gene Names
UniProt Entry Name
EHMT2_MOUSE
UniProt Comments for EHMT2
EHMT2: Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Methyltransferase
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleolus; chromosome; nucleus
Molecular Function: methyltransferase activity; trimethylamine methyltransferase activity; monomethylamine methyltransferase activity; RNA methyltransferase activity; tRNA (cytosine)-methyltransferase activity; rRNA (cytosine-C5-967)-methyltransferase activity; rRNA (uridine) methyltransferase activity; N-methyltransferase activity; histone-lysine N-methyltransferase activity; tRNA (guanine) methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific); rRNA (adenine-N6,N6-)-dimethyltransferase activity; arginine N-methyltransferase activity; selenocysteine methyltransferase activity; methanol-specific methylcobalamin:coenzyme M methyltransferase activity; protein-arginine N-methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; dimethylamine methyltransferase activity; protein methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; transferase activity; hydroxyneurosporene-O-methyltransferase activity; rRNA (uridine-2'-O-)-methyltransferase activity; tRNA (uracil) methyltransferase activity; rRNA (adenine) methyltransferase activity; histone lysine N-methyltransferase activity (H3-K9 specific); C-methyltransferase activity; cobalt-precorrin-6B C5-methyltransferase activity; cobalt-precorrin-3 C17-methyltransferase activity; 1-phenanthrol methyltransferase activity; zinc ion binding; metal ion binding; S-methyltransferase activity; lysine N-methyltransferase activity; DNA-methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; tRNA (adenine)-methyltransferase activity; rRNA (cytosine) methyltransferase activity; cobalt-precorrin-7 C15-methyltransferase activity; protein-arginine N5-methyltransferase activity; rRNA methyltransferase activity; p53 binding; protein-leucine O-methyltransferase activity; demethylmenaquinone methyltransferase activity; rRNA (adenine-N6-)-methyltransferase activity; tRNA methyltransferase activity; rRNA (guanine) methyltransferase activity; methylarsonite methyltransferase activity; protein binding; mRNA methyltransferase activity; methylamine-specific methylcobalamin:coenzyme M methyltransferase activity; tRNA (guanine-N1-)-methyltransferase activity; cobalt-precorrin-5B C1-methyltransferase activity; protein-lysine N-methyltransferase activity; O-methyltransferase activity; tRNA (adenine-N1-)-methyltransferase activity; tRNA (adenine-57, 58-N(1)-) methyltransferase activity
Biological Process: methylation; synaptonemal complex assembly; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; germ cell development; peptidyl-lysine methylation; regulation of transcription from RNA polymerase II promoter; histone methylation; organ growth; cytosine methylation within a CG sequence; fertilization; long-term memory; peptidyl-lysine di-methylation; DNA methylation; regulation of histone H3-K4 methylation; regulation of histone H3-K9 methylation; spermatid development; histone H3-K9 methylation; regulation of DNA replication
Research Articles on EHMT2
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Pathways associated with EHMT2 elisa kit
Diseases associated with EHMT2 elisa kit
Organs/Tissues associated with EHMT2 elisa kit
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