NP_085042.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,766 Da
NCBI Official Full Name
extracellular serine/threonine protein kinase FAM20C
NCBI Official Synonym Full Names
family with sequence similarity 20, member C
NCBI Official Synonym Symbols
DMP4; DMP-4; C76981; GEF-CK; mKIAA4081 [Similar Products]
NCBI Protein Information
extracellular serine/threonine protein kinase FAM20C; dentin matrix protein 4; golgi-enriched fraction casein kinase
UniProt Protein Name
Extracellular serine/threonine protein kinase FAM20C
UniProt Synonym Protein Names
Dentin matrix protein 4; DMP-4; Golgi-enriched fraction casein kinase; GEF-CK
UniProt Synonym Gene Names
UniProt Entry Name
DMP4_MOUSE
UniProt Comments for FAM20C
FAM20C: an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Secreted, signal peptide; Protein kinase, Ser/Thr (non-receptor); Secreted
Cellular Component: Golgi apparatus; extracellular space; extracellular region
Molecular Function: transferase activity; protein serine/threonine kinase activity; metal ion binding; calcium ion binding; kinase activity
Biological Process: positive regulation of osteoblast differentiation; biomineral formation; regulation of fibroblast growth factor receptor signaling pathway; positive regulation of bone mineralization; skeletal development; protein amino acid phosphorylation; phosphorylation; regulation of phosphorus metabolic process
Research Articles on FAM20C
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Diseases associated with FAM20C elisa kit
Organs/Tissues associated with FAM20C elisa kit
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