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GABRA1 elisa kit :: Mouse gamma-aminobutyric acid (GABA) A receptor, alpha 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9339158 GABRA1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), ELISA Kit

 Also Known As   

Mouse Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1 ELISA Kit

 Product Synonym Names    Mouse Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ELISA kit; ECA4; EJM; EJM5; ; gamma-aminobutyric acid (GABA) A receptor; alpha 1
 Product Gene Name   

GABRA1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 3D Structure    ModBase 3D Structure for P62812
 Species Reactivity    Mouse
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 Specificity    No significant cross-reactivity or interference between Mouse GABRA1 and analogues was observed.
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 Samples    Serum, Plasma, Tissue Homogenate, Feces and Urine
 Assay Type    Sandwich
 Detection Range    0.5mumol/L-16mumol/L.
 Sensitivity    0.1mumol/L.
 Intended Uses    This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated GABRA1 concentrations in Human serum, plasma and other body fluids. Using Purified Human GABRA1 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add GABRA1 and GABRA1 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of GABRA1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Intray-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100]
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of GABRA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GABRA1 purchase    MBS9339158 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5mumol/L-16mumol/L in biological research samples containing GABRA1, with an estimated sensitivity of 0.1mumol/L. The ELISA analytical biochemical technique of the MBS9339158 kit is based on GABRA1 antibody-GABRA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABRA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABRA1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue Homogenate, Feces and Urine. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for GABRA1 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated GABRA1 concentrations in Human serum, plasma and other body fluids. Using Purified Human GABRA1 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add GABRA1 and GABRA1 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of GABRA1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
Sample Manual Insert of MBS9339158
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NCBI/Uniprot data below describe general gene information for GABRA1. It may not necessarily be applicable to this product.
 NCBI GI #    6753936
 NCBI GeneID    14394
 NCBI Accession #    NP_034380.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010250.5 [Other Products]
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 UniProt Primary Accession #    P62812 [Other Products]
 UniProt Secondary Accession #    P18504 [Other Products]
 UniProt Related Accession #    P62812 [Other Products]
 Molecular Weight    51,754 Da
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit alpha-1
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
 NCBI Official Symbol    Gabra1 [Similar Products]
 NCBI Official Synonym Symbols   
Gabra-1
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit alpha-1; GABAA alpha 1; GABAAR alpha1; GABA(A) receptor subunit alpha-1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit alpha-1
 UniProt Synonym Protein Names   
GABA(A) receptor subunit alpha-1
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    Gabra1 [Similar Products]
 UniProt Synonym Gene Names    Gabra-1 [Similar Products]
 UniProt Entry Name    GBRA1_MOUSE
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 UniProt Comments for GABRA1    GABRA1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.

Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Cellular Component: postsynaptic membrane; membrane; integral to plasma membrane; integral to membrane; plasma membrane; synapse; cell junction

Molecular Function: chloride channel activity; protein binding; GABA-A receptor activity; GABA receptor activity; ion channel activity; drug binding; extracellular ligand-gated ion channel activity

Biological Process: transport; synaptic transmission, GABAergic; ion transport; chloride transport; gamma-aminobutyric acid signaling pathway
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 Research Articles on GABRA1    1. these findings suggest that gephyrin may be a key factor in BDNF-dependent GABAAR regulation in the amygdala.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GABRA1 elisa kitDiseases associated with GABRA1 elisa kit
 Products by Pathway  Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >75 publications with GABRA1 and Nervous System Diseases
 Epilepsy Antibodies  >68 publications with GABRA1 and Epilepsy
 Brain Diseases Antibodies  >63 publications with GABRA1 and Brain Diseases
 Seizures Antibodies  >33 publications with GABRA1 and Seizures
 Mental Disorders Antibodies  >31 publications with GABRA1 and Mental Disorders
 Epilepsies, Myoclonic Antibodies  >18 publications with GABRA1 and Epilepsies, Myoclonic
 Myoclonic Epilepsy, Juvenile Antibodies  >17 publications with GABRA1 and Myoclonic Epilepsy, Juvenile
 Schizophrenia Antibodies  >13 publications with GABRA1 and Schizophrenia
 Substance-Related Disorders Antibodies  >9 publications with GABRA1 and Substance-Related Disorders
 Mood Disorders Antibodies  >7 publications with GABRA1 and Mood Disorders
Organs/Tissues associated with GABRA1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >126 publications with GABRA1 and Brain
 Spinal Cord Antibodies  >7 publications with GABRA1 and Spinal Cord
 Eye Antibodies  >2 publications with GABRA1 and Eye
 Prostate Antibodies  >1 publications with GABRA1 and Prostate
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