NP_062312.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,216 Da
NCBI Official Full Name
gamma-aminobutyric acid type B receptor subunit 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) B receptor, 1
NCBI Protein Information
gamma-aminobutyric acid type B receptor subunit 1; gb1; GABA-BR1; GABA-B-R1; GABA-B receptor 1; GABA-BR1b receptor; gamma-aminobutyric acid (GABA-B) receptor, 1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
UniProt Protein Name
Gamma-aminobutyric acid type B receptor subunit 1
UniProt Synonym Gene Names
UniProt Entry Name
GABR1_MOUSE
UniProt Comments for GABBR1
GABBR1: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral
Cellular Component: extracellular space; endoplasmic reticulum membrane; neuron projection; intracellular membrane-bound organelle; integral to plasma membrane; dendritic spine; integral to membrane; axolemma; lipid raft; presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell projection; membrane; cell soma; cytoplasm; mitochondrial membrane; plasma membrane; synapse; dendritic shaft; cell junction
Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; GABA-B receptor activity; transcription factor binding
Biological Process: regulation of glutamate secretion; negative regulation of adenylate cyclase activity; negative regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; signal transduction; negative regulation of synaptic transmission; osteoblast differentiation; positive regulation of growth hormone secretion; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; negative regulation of epinephrine secretion; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of cAMP biosynthetic process; negative regulation of dopamine secretion; gamma-aminobutyric acid signaling pathway
Research Articles on GABBR1
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Pathways associated with GABBR1 elisa kit
Diseases associated with GABBR1 elisa kit
Organs/Tissues associated with GABBR1 elisa kit
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