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gp130 elisa kit :: Mouse gp130 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2504330
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

gp130, ELISA Kit

★Popular Item★
 Also Known As   

Mouse gp130 (Glucoprotein 130) ELISA Kit

 Product Gene Name   

gp130 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600694
 3D Structure    ModBase 3D Structure for P40189
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse gp130. No significant cross-reactivity or interference between Mouse gp130 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse gp130 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    125-8000pg/mL
 Sensitivity    Min: 75pg/mL; Max: 8000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of gp130 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for gp130 purchase    MBS2504330 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gp130, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 125-8000pg/mL in biological research samples containing gp130, with an estimated sensitivity of Min: 75pg/mL; Max: 8000pg/mL. The ELISA analytical biochemical technique of the MBS2504330 kit is based on gp130 antibody-gp130 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect gp130 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, gp130. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for gp130 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of gp130 in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse gp130. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse gp130 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse gp130, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse gp130. You can calculate the concentration of Mouse gp130 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of gp130 elisa kit    gp130 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2504330. Click to request current manual
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NCBI/Uniprot data below describe general gene information for gp130. It may not necessarily be applicable to this product.
 NCBI GI #    1246098
 NCBI GeneID    3572
 NCBI Accession #    AAB35921.1 [Other Products]
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 UniProt Primary Accession #    P40189 [Other Products]
 UniProt Secondary Accession #    Q5FC04; Q9UQ41; A0N0L4 [Other Products]
 UniProt Related Accession #    P40189 [Other Products]
 Molecular Weight    96,276 Da
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 NCBI Official Full Name    gp130, partial
 NCBI Official Synonym Full Names    interleukin 6 signal transducer
 NCBI Official Symbol    IL6ST [Similar Products]
 NCBI Official Synonym Symbols   
CD130; GP130; CDW130; IL-6RB
[Similar Products]
 NCBI Protein Information    interleukin-6 receptor subunit beta; CD130 antigen; IL-6 receptor subunit beta; IL-6R subunit beta; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; interleukin receptor beta chain; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha
 UniProt Protein Name    Interleukin-6 receptor subunit beta
 UniProt Synonym Protein Names   
CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
 UniProt Gene Name    IL6ST [Similar Products]
 UniProt Synonym Gene Names    IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130 [Similar Products]
 UniProt Entry Name    IL6RB_HUMAN
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 NCBI Summary for gp130    The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
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 UniProt Comments for gp130    gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; extracellular region; plasma membrane; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: interleukin-11 binding; interleukin-27 receptor activity; protein homodimerization activity; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 receptor binding; interleukin-6 binding; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: glycogen metabolic process; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; viral reproduction; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; cytokine and chemokine mediated signaling pathway; response to cytokine stimulus; leukemia inhibitory factor signaling pathway; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of apoptosis; positive regulation of astrocyte differentiation
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 Research Articles on gp130    1. Low incidence of IL6ST mutations in exon 6 are associated with lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with gp130 elisa kitPathways associated with gp130 elisa kit
 Reference Product  PubMed Publications
 STAT3 elisa kit  >286 publications with gp130 and STAT3
 LIF elisa kit  >237 publications with gp130 and LIF
 OSM elisa kit  >178 publications with gp130 and OSM
 CNTF elisa kit  >112 publications with gp130 and CNTF
 STAT1 elisa kit  >69 publications with gp130 and STAT1
 JAK1 elisa kit  >51 publications with gp130 and JAK1
 IL6 elisa kit  >46 publications with gp130 and IL6
 SOCS3 elisa kit  >37 publications with gp130 and SOCS3
 PTPN11 elisa kit  >32 publications with gp130 and PTPN11
 IL6R elisa kit  >20 publications with gp130 and IL6R
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with gp130 elisa kitOrgans/Tissues associated with gp130 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >117 publications with gp130 and Inflammation
 Cardiovascular Diseases Antibodies  >102 publications with gp130 and Cardiovascular Diseases
 Carcinoma Antibodies  >59 publications with gp130 and Carcinoma
 Disease Models, Animal Antibodies  >52 publications with gp130 and Disease Models, Animal
 Nervous System Diseases Antibodies  >51 publications with gp130 and Nervous System Diseases
 Heart Diseases Antibodies  >48 publications with gp130 and Heart Diseases
 Necrosis Antibodies  >44 publications with gp130 and Necrosis
 Liver Diseases Antibodies  >38 publications with gp130 and Liver Diseases
 Hypertrophy Antibodies  >31 publications with gp130 and Hypertrophy
 Arthritis, Rheumatoid Antibodies  >25 publications with gp130 and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >213 publications with gp130 and Blood
 Liver Antibodies  >87 publications with gp130 and Liver
 Bone Antibodies  >82 publications with gp130 and Bone
 Brain Antibodies  >78 publications with gp130 and Brain
 Heart Antibodies  >72 publications with gp130 and Heart
 Muscle Antibodies  >64 publications with gp130 and Muscle
 Bone Marrow Antibodies  >57 publications with gp130 and Bone Marrow
 Nerve Antibodies  >56 publications with gp130 and Nerve
 Vascular Antibodies  >34 publications with gp130 and Vascular
 Embryonic Tissue Antibodies  >33 publications with gp130 and Embryonic Tissue
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