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GZMA elisa kit :: Mouse granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS704766 GZMA elisa kit
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $575 +1 FREE 8GB USB
96-Strip-Wells  /  $835 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,040 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,755 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (GZMA), ELISA Kit

★Popular Item★
 Also Known As   

Mouse granzymes A, Gzms-A ELISA Kit

 Product Synonym Names    Mouse granzymes A; Gzms-A ELISA Kit; CTLA3; HFSP; CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease) ; granzyme A; granzyme A (granzyme 1; cytotoxic T-lymphocyte-associated serine esterase 3)
 Product Gene Name   

GZMA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P11032
 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse GZMA. No significant cross-reactivity or interference between mouse GZMA and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Detection Range    6.25 pg/ml -400 pg/mL
 Sensitivity    <1.56 pg/mL
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GZMA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GZMA purchase    MBS704766 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (GZMA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25 pg/ml -400 pg/mL in biological research samples containing GZMA, with an estimated sensitivity of <1.56 pg/mL. The ELISA analytical biochemical technique of the MBS704766 kit is based on GZMA antibody-GZMA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GZMA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GZMA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GZMA elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for GZMA has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any GZMA present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GZMA is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GZMA bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS704766. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GZMA. It may not necessarily be applicable to this product.
 NCBI GI #    6754102
 NCBI GeneID    14938
 NCBI Accession #    NP_034500.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010370.2 [Other Products]
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 UniProt Primary Accession #    P11032 [Other Products]
 UniProt Secondary Accession #    P15118 [Other Products]
 UniProt Related Accession #    P11032 [Other Products]
 Molecular Weight    28,599 Da
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 NCBI Official Full Name    granzyme A
 NCBI Official Synonym Full Names    granzyme A
 NCBI Official Symbol    Gzma [Similar Products]
 NCBI Official Synonym Symbols   
Hf; SE1; TSP1; Ctla3; TSP-1; Ctla-3; AW494114
[Similar Products]
 NCBI Protein Information    granzyme A; H factor; BLT esterase; fragmentin-1; Hanukah factor; serine esterase 1; t cell-specific serine protease 1; autocrine thymic lymphoma granzyme-like serine protease
 UniProt Protein Name    Granzyme A
 UniProt Synonym Protein Names   
Autocrine thymic lymphoma granzyme-like serine protease; CTLA-3; Fragmentin-1; T cell-specific serine protease 1; TSP-1
 Protein Family    Granzyme
 UniProt Gene Name    Gzma [Similar Products]
 UniProt Synonym Gene Names    Ctla-3; Ctla3; Mtsp-1; TSP-1 [Similar Products]
 UniProt Entry Name    GRAA_MOUSE
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 UniProt Comments for GZMA    Function: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA

Catalytic activity: Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates.
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 Research Articles on GZMA    1. functional divergence between human and mouse granzyme A
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GZMA elisa kitPathways associated with GZMA elisa kit
 Reference Product  PubMed Publications
 SET elisa kit  >12 publications with GZMA and SET
 HMGB2 elisa kit  >5 publications with GZMA and HMGB2
 APEX1 elisa kit  >5 publications with GZMA and APEX1
 Products by Pathway  Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with GZMA elisa kitOrgans/Tissues associated with GZMA elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >33 publications with GZMA and Necrosis
 Inflammation Antibodies  >19 publications with GZMA and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with GZMA and Cardiovascular Diseases
 Gastrointestinal Diseases Antibodies  >5 publications with GZMA and Gastrointestinal Diseases
 Lung Diseases Antibodies  >4 publications with GZMA and Lung Diseases
 Liver Diseases Antibodies  >4 publications with GZMA and Liver Diseases
 Blood Coagulation Disorders Antibodies  >3 publications with GZMA and Blood Coagulation Disorders
 Liver Neoplasms Antibodies  >3 publications with GZMA and Liver Neoplasms
 Kidney Diseases Antibodies  >2 publications with GZMA and Kidney Diseases
 Lung Injury Antibodies  >2 publications with GZMA and Lung Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >258 publications with GZMA and Blood
 Lung Antibodies  >10 publications with GZMA and Lung
 Skin Antibodies  >10 publications with GZMA and Skin
 Spleen Antibodies  >9 publications with GZMA and Spleen
 Kidney Antibodies  >9 publications with GZMA and Kidney
 Intestine Antibodies  >8 publications with GZMA and Intestine
 Heart Antibodies  >7 publications with GZMA and Heart
 Lymph Node Antibodies  >5 publications with GZMA and Lymph Node
 Uterus Antibodies  >4 publications with GZMA and Uterus
 Placenta Antibodies  >2 publications with GZMA and Placenta
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