NP_666113.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
115,202 Da
NCBI Official Full Name
huntingtin-interacting protein 1
NCBI Official Synonym Full Names
huntingtin interacting protein 1
NCBI Official Synonym Symbols
mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik [Similar Products]
NCBI Protein Information
huntingtin-interacting protein 1; HIP-I; huntingtin-interacting protein I
UniProt Protein Name
Huntingtin-interacting protein 1
UniProt Synonym Protein Names
Huntingtin-interacting protein I; HIP-I
UniProt Synonym Gene Names
UniProt Entry Name
HIP1_MOUSE
UniProt Comments for HIP1
HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Apoptosis
Cellular Component: Golgi apparatus; membrane; intracellular membrane-bound organelle; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; nucleus
Molecular Function: clathrin binding; protein binding; phospholipid binding; actin binding; phosphoinositide binding
Biological Process: regulation of apoptosis; caspase activation; clathrin cage assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; endocytosis; cell differentiation; positive regulation of receptor-mediated endocytosis
Research Articles on HIP1
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Pathways associated with HIP1 elisa kit
Diseases associated with HIP1 elisa kit
Organs/Tissues associated with HIP1 elisa kit
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