NP_032318.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,482 Da
NCBI Official Full Name
peroxisomal multifunctional enzyme type 2
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 4
NCBI Official Synonym Symbols
4; DBP; MFP2; MFE-2; MPF-2; Mfp-2; perMFE-2; 17[b]-HSD; 17-beta-HSD [Similar Products]
NCBI Protein Information
peroxisomal multifunctional enzyme type 2; 17-beta-HSD 4; D-bifunctional protein; multifunctional protein 2; 17-beta-hydroxysteroid dehydrogenase 4
UniProt Protein Name
Peroxisomal multifunctional enzyme type 2
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2
UniProt Synonym Gene Names
UniProt Entry Name
DHB4_MOUSE
UniProt Comments for HSD17B4
HSD17B4: Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD). DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Defects in HSD17B4 are the cause of Perrault syndrome (PRS). PRS is a sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Cell development/differentiation; EC 1.1.1.n12; Oxidoreductase; Lyase; Mitochondrial; Lipid Metabolism - primary bile acid biosynthesis; EC 4.2.1.107; EC 4.2.1.119
Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; membrane; mitochondrion; peroxisome
Molecular Function: protein homodimerization activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; lyase activity; long-chain-enoyl-CoA hydratase activity; isomerase activity; oxidoreductase activity; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding
Biological Process: osteoblast differentiation; estrogen metabolic process; fatty acid beta-oxidation; very-long-chain fatty acid metabolic process; metabolic process; androgen metabolic process; lipid metabolic process; fatty acid metabolic process; Sertoli cell development
Research Articles on HSD17B4
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Pathways associated with HSD17B4 elisa kit
Diseases associated with HSD17B4 elisa kit
Organs/Tissues associated with HSD17B4 elisa kit
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