NP_001074582.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,078 Da
NCBI Official Full Name
importin-8
NCBI Official Synonym Full Names
importin 8
NCBI Official Synonym Symbols
Om1; MRP7; OM-1; Abcc10; Ranbp8; 6230418K12Rik; C130009K11Rik [Similar Products]
NCBI Protein Information
importin-8; imp8; oocyte maturation 1; ran-binding protein 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 10
UniProt Protein Name
Importin-8
UniProt Synonym Protein Names
Ran-binding protein 8; RanBP8
UniProt Synonym Gene Names
UniProt Entry Name
IPO8_MOUSE
UniProt Comments for IPO8
IPO8: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear import; G protein regulator, misc.; Karyopherin; Nuclear export
Cellular Component: integral to plasma membrane; cytoplasm; nucleus
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; Ran GTPase binding
Biological Process: intracellular protein transport; protein transport; transport; transmembrane transport
Research Articles on IPO8
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Diseases associated with IPO8 elisa kit
Organs/Tissues associated with IPO8 elisa kit
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