NP_032346.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
48,237 Da
NCBI Official Full Name
interferon regulatory factor 8
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Official Synonym Symbols
Myls; ICSBP; IRF-8; Icsbp1; AI893568 [Similar Products]
NCBI Protein Information
interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1
UniProt Protein Name
Interferon regulatory factor 8
UniProt Synonym Protein Names
Interferon consensus sequence-binding protein; ICSBP
UniProt Synonym Gene Names
UniProt Entry Name
IRF8_MOUSE
NCBI Summary for IRF8
The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for IRF8
IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.
Protein type: Transcription factor; DNA-binding
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: positive regulation of interferon-gamma production; response to bacterium; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; defense response to bacterium; immune response; myeloid cell differentiation; defense response to protozoan; phagocytosis
Research Articles on IRF8
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Pathways associated with IRF8 elisa kit
Diseases associated with IRF8 elisa kit
Organs/Tissues associated with IRF8 elisa kit
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